Evidence map›Paper›PMID 35908968›Full record

ArticleInternal medicine (Tokyo, Japan)2023

Demyelinating Neuropathy with Markedly Elevated Serum IgG4 Levels and Anti-Contactin 1 IgG4 Antibody.

Taiki Fukushima, Shohei Ikeda, Minoru Tomita, Yu Mori, Yuki Fukami, Haruki Koike, Masahisa Katsuno, Hidenori Ogata, Noriko Isobe, Naoki Hattori

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Taiki FukushimaDepartment of Neurology, Toyota Kosei Hospital, Japan.
Shohei IkedaDepartment of Neurology, Toyota Kosei Hospital, Japan.
Minoru TomitaDepartment of Neurology, Toyota Kosei Hospital, Japan.
Yu MoriDepartment of Neurology, Gifu Prefectural Tajimi Hospital, Japan.
Yuki FukamiDepartment of Neurology, Nagoya University Graduate School of Medicine, Japan.
Haruki KoikeDepartment of Neurology, Nagoya University Graduate School of Medicine, Japan.
Masahisa KatsunoDepartment of Neurology, Nagoya University Graduate School of Medicine, Japan.
Hidenori OgataDepartment of Neurology, Graduate School of Medical Sciences, Kyushu University, Japan.
Noriko IsobeDepartment of Neurology, Graduate School of Medical Sciences, Kyushu University, Japan.
Naoki HattoriDepartment of Neurology, Toyota Kosei Hospital, Japan.
Toyota Kosei Hospital · JPNagoya University · JPKyushu University · JPGifu Prefectural Tajimi Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We herein report a 77-year-old man with a 4-month history of progressive gait and sensory disturbances of the extremities. A nerve conduction study indicated demyelinating polyneuropathy. Serum IgG4 levels and anti-contactin 1 IgG4 antibodies were markedly increased. The sural nerve biopsy specimen showed IgG4-positive plasma cell infiltration in the epineurium. Treatment with steroids resulted in an amelioration of functional status, improvement of nerve conduction parameters, decreased serum IgG4 levels, and negative conversion of anti-contactin 1 antibody. Further studies are needed to clarify the significance of IgG4-positive plasma cell infiltration in anti-contactin 1 antibody-positive neuropathies.

Indexed as

Peripheral Nervous System DiseasesPolyradiculoneuropathy, Chronic Inflammatory DemyelinatingAgedAutoantibodiesContactin 1HumansImmunoglobulin GInflammationMaleNeural ConductionPeripheral NervesAutoantibodiesContactin 1Immunoglobulin GChronic inflammatory demyelinating polyneuropathycontactin 1intravenous immunoglobulin therapysteroid therapy

Identifiers

PMID35908968
PMCPMC10208785
OpenAlexW4288474578

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.