Evidence map›Paper›PMID 35908882›Full record

Observational studyJournal of atherosclerosis and thrombosis2023

Significant Impact of Age on Mortality and Non-significant Impact of Age on Thrombosis and Major Bleeding in Patients with COVID-19: From the CLOT-COVID Study.

Yugo Yamashita, Sen Yachi, Makoto Takeyama, Yuji Nishimoto, Ichizo Tsujino, Junichi Nakamura, Naoto Yamamoto, Hiroko Nakata, Satoshi Ikeda, Michihisa Umetsu and 13 more

Abstract readObservational StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of atherosclerosis and thrombosis, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Yugo YamashitaKyoto University Hospital.
Sen YachiJapan Community Health Care Organization Tokyo Shinjuku Medical Center.
Makoto TakeyamaJapan Community Health Care Organization Tokyo Shinjuku Medical Center.
Yuji NishimotoHyogo Prefectural Amagasaki General Medical Center.
Ichizo TsujinoHokkaido University Hospital.
Junichi NakamuraHokkaido University Hospital.
Naoto YamamotoHamamatsu Medical Center.
Hiroko NakataYokosuka General Hospital Uwamachi.
Satoshi IkedaNagasaki University Graduate School of Biomedical Sciences.
Michihisa UmetsuTohoku University Hospital.
Shizu AikawaTsukuba Medical Center Hospital.
Hiroya HayashiOsaka Metropolitan University Graduate School of Medicine.
Hirono SatokawaFukushima Medical University, School of Medicine.
Yoshinori OkunoKyoto University Hospital.
Eriko IwataNankai Medical Center Japan Community Health Care Organization.
Yoshito OgiharaMie University Hospital.
Nobutaka IkedaToho University Ohashi Medical Center.
Akane KondoShikoku Medical Center for Children and Adults.
Takehisa IwaiTsukuba Vascular Center.
Norikazu YamadaKuwana City Medical Center.
Tomohiro OgawaFukushima Daiich Hospital.
Takao KobayashiHamamatsu Medical Center.
Makoto MoYokohama Minami Kyosai Hospital.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThere is scarce data on the impact of age on clinical outcomes in patients with coronavirus disease 2019 (COVID-19).

methodThe CLOT-COVID Study was a retrospective, multicenter cohort study enrolling 2894 consecutive hospitalized patients with COVID-19 among 16 centers in Japan from April 2021 to September 2021. We divided the entire cohort into five groups according to age strata; -19, 20-39, 40-59, 60-79, and 80- years.

resultsMost patients under 19 had mild COVID-19 on admission (99%), while older patients had more severe COVID-19. The incidence rates of clinical outcomes during hospitalization in patients aged ≤ 19, 20-39, 40-59, 60-79, and 80 ≥ years were 0.0%, 0.5%, 2.2%, 2.7%, and 1.5% for thrombosis; 0.0%, 1.2%, 1.5%, 3.4%, and 2.0% for major bleeding; and 0.0%, 0.4%, 2.0%, 12.1%, and 16.8% for all-cause death, respectively. In the stratified analysis according to COVID-19 severity on admission, the incidences of thrombosis were generally higher among patients with more severe status, although those were not significantly different among age strata in all sub-types of COVID-19 severity. However, the incidences of all-cause death were significantly higher with increasing age in all sub-types of COVID-19 severity.

conclusionsIn the current large observational study of patients with COVID-19, the risk of mortality became markedly higher with increased age. However, the risks of thrombosis and major bleeding did not necessarily increase as age increases, which seemed to be consistent irrespective of COVID-19 severity on admission.

Indexed as

COVID-19ThrombosisAdolescentAdultAgedAged, 80 and overChildChild, PreschoolCohort StudiesHemorrhageHospitalizationHumansInfantInfant, NewbornMiddle AgedRetrospective StudiesAgeBleedingCOVID-19MortalityThrombosis

Identifiers

PMID35908882
PMCPMC10244071

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LicenceCC BY-NC-SA
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.