ReviewDrugs & aging2022
Hormonal Agents for the Treatment of Depression Associated with the Menopause.
Review in Drugs & aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07165964 (Nursing Interventions to Enhance Positive Mental Health and Self Care in Women During the Climacteric), which is not on this map. Cited by 52 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Nursing Interventions to Enhance Positive Mental Health and Self Care in Women During the Climacteric
Who cites it
52 citing papers in PubMed, 7 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- ADHD and Sex Hormones in Females: A Systematic Review.Journal of attention disorders · 2025Pooled it
- Effects of physical activity on depressive and anxiety symptoms of women in the menopausal transition and menopause: a comprehensive systematic review and meta-analysis of randomized controlled trials.The international journal of behavioral nutrition and physical activity · 2025Pooled it
- Mind-body therapies for sleep disturbances, depression, and anxiety in menopausal women: a systematic review and meta-analysis of randomized controlled trials.Frontiers in public health · 2025Pooled it
- Brazilian Guideline on Menopausal Cardiovascular Health - 2024.Arquivos brasileiros de cardiologia · 2024Guideline
- Pooled it
- Does menopause elevate the risk for developing depression and anxiety? Results from a systematic review.Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists · 2023Pooled it
- Menopause and suicide: A systematic review.Women's health (London, England)Pooled it
- Effect of breathing exercises on depression, sexual function, and exercise capacity in postmenopausal women: a randomized controlled trial.Scientific reports · 2026Trial
- Effects of jazz dance and concurrent training on psychological variables in menopausal women: A randomized controlled trial.Archives of women's mental health · 2025Trial
- Menopausal Suicidality and Fragmented Care: A Qualitative Study of Carer and Clinician Perspectives.Health expectations : an international journal of public participation in health care and health policy · 2026Article
- Nutritional Interventions for Perimenopausal Anxiety and Depression Targeting Tryptophan and GABA Pathways: A Narrative Review.Nutrients · 2026Review
- Chronic Opioid Use and Endocrine Disruption in Women: Mechanisms, Life-Course Vulnerabilities, and Reproductive Health Implications.Journal of xenobiotics · 2026Review
- Cognitive dysfunction in women with theJournal of Alzheimer's disease : JAD · 2026Article
- Research advances on estrogen deficiency leading to depression.Translational neuroscience · 2026Review
- Exploring women's experiences and needs during the climacteric to enhance positive mental health and self-care.Frontiers in global women's health · 2026Article
- Gender Differences and Comorbidities in Major Depression.Advances in experimental medicine and biology · 2026Review
- Impact of Obesity, Menopause, and Depression in Women's Health: An Attempt to Decipher the Complex Relationship.Current medicinal chemistry · 2026Review
- Menopause and Mental Health.Advances in therapy · 2026Review
- Gender differences in gray matter volume of the anterior cingulate cortex and suicidal ideation in patients with major depressive disorder: evidence from the REST-meta-MDD project.Translational psychiatry · 2025Article
- Depression Symptom Trajectories in Mothers With the FMR1 Premutation Vary by CGG Repeat Length: A Longitudinal Study of 73 Women Spanning 20-75 Years of Age.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Perimenopause marks the transition from a woman's reproductive stage to menopause. Usually occurring between 42 and 52 years of age, it is determined clinically by the onset of irregular menstrual cycles or variable cycle lengths. Women are at an increased risk of depression and anxiety during perimenopause and the menopausal transition. Depressive symptoms experienced in perimenopause are often more severe compared to pre- and post-menopause. During menopausal transition, the impact of fluctuating estrogen in the central nervous system (CNS) can have negative psychological effects for some women. Traditional first-line management of menopausal depression involves antidepressants, with modest outcomes. The positive effects of estrogen treatment in the CNS are becoming increasingly recognised, and hormonal therapy (HT) with estrogen may have a role in the treatment of menopausal depression. In this review we will outline the prevalence, impact and neurochemical basis of menopausal-associated depression, as well as hormone-based approaches that have increasing promise as effective treatments.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.