Evidence map›Paper›PMID 35908116›Full record

ArticleEuropean archives of psychiatry and clinical neuroscience2023

Real-time fMRI neurofeedback compared to cognitive behavioral therapy in a pilot study for the treatment of mild and moderate depression.

Mikhail Ye Mel'nikov, Dmitriy D Bezmaternykh, Andrey A Savelov, Evgeniy D Petrovskiy, Lyudmila I Kozlova, Kira A Natarova, Tatiana D Larina, Tatiana M Andamova, Mikhail Zvyagintsev, Mark B Shtark and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European archives of psychiatry and clinical neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Effectiveness of fMRI-based Neurofeedback Therapy on Depression: A Systematic Review.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Mikhail Ye Mel'nikovFederal Research Center of Fundamental and Translational Medicine, Research Institute of Molecular Biology and Biophysics, Russian Federation, 2 Timakova str., Novosibirsk, Russia.ORCID http://orcid.org/0000-0003-4957-1958
Dmitriy D BezmaternykhFederal Research Center of Fundamental and Translational Medicine, Research Institute of Molecular Biology and Biophysics, Russian Federation, 2 Timakova str., Novosibirsk, Russia.ORCID http://orcid.org/0000-0001-6712-5412
Andrey A SavelovInternational Tomography Center, Russian Federation, 3a Institutskaya str., Novosibirsk, Russia.ORCID http://orcid.org/0000-0002-5332-2607
Evgeniy D PetrovskiyInternational Tomography Center, Russian Federation, 3a Institutskaya str., Novosibirsk, Russia.ORCID http://orcid.org/0000-0003-4325-4062
Lyudmila I KozlovaFederal Research Center of Fundamental and Translational Medicine, Research Institute of Molecular Biology and Biophysics, Russian Federation, 2 Timakova str., Novosibirsk, Russia.ORCID http://orcid.org/0000-0003-1821-7251
Kira A NatarovaInternational Institute of Psychology and Psychotherapy, Russian Federation, 2 Serebrennikovskaya str., Novosibirsk, Russia.ORCID http://orcid.org/0000-0001-8088-0471
Tatiana D LarinaState Novosibirsk Clinical Psychiatry Hospital №3, Russian Federation, 2 Vladimirovskaya str., Novosibirsk, Russia.
Tatiana M AndamovaFederal Research Center of Fundamental and Translational Medicine, Research Institute of Molecular Biology and Biophysics, Russian Federation, 2 Timakova str., Novosibirsk, Russia.
Mikhail ZvyagintsevRWTH Aachen University, Universitätsklinikum Aachen, 30 Pauwelsstrasse, Aachen, Germany.ORCID http://orcid.org/0000-0001-9521-042X
Mark B ShtarkFederal Research Center of Fundamental and Translational Medicine, Research Institute of Molecular Biology and Biophysics, Russian Federation, 2 Timakova str., Novosibirsk, Russia.ORCID http://orcid.org/0000-0002-2326-4709
Klaus MathiakRWTH Aachen University, Universitätsklinikum Aachen, 30 Pauwelsstrasse, Aachen, Germany. kmathiak@ukaachen.de.ORCID http://orcid.org/0000-0002-2276-7726
Federal Research Center of Fundamental and Translational Medicine · RUInternational Tomography Center · RUUniversitätsklinikum Aachen · DECity Clinical Hospital No. 2 · RUInstitute of Psychology · RU

Funding

Bundesministerium für Bildung und Forschung 01EE1405ABundesministerium für Bildung und Forschung BBundesministerium für Bildung und Forschung C; 01DN18026Deutsche Forschungsgemeinschaft IRTG 2150Deutsche Forschungsgemeinschaft MA 2631/6-1Russian Science Support Foundation 16-15-00183
6 · The paper itself

Abstract

Real-time functional magnetic resonance imaging (rt-fMRI) neurofeedback was found to reduce depressive symptoms. However, no direct comparison of drug-free patients with an active psychotherapy control group is available. The present study compared rt-fMRI neurofeedback with cognitive behavioral therapy, as the standard treatment in patients declining anti-depressants. Twenty adult, drug-free patients with mild or moderate depression were non-randomly assigned either to a course of eight half-hour sessions of neurofeedback targeting the left medial prefrontal cortex (N = 12) or to a 16-session course of cognitive behavioral therapy (N = 8). Montgomery-Asberg Depression Rating Scale was introduced at baseline, mid-treatment, and end-treatment points. In each group, 8 patients each remained in the study to a mid-treatment evaluation and 6 patients each to the study end-point. ANOVA revealed a depression reduction with a significant effect of Time (F(3,6) = 19.0, p < 0.001, η

Indexed as

Cognitive Behavioral TherapyDepressive DisorderAdultDepressionHumansMagnetic Resonance ImagingPilot ProjectsCognitive behavioral therapyDepressionLearning curvesMedial prefrontal cortexReal-time functional magnetic resonance imaging neurofeedback (rt-fMRI NFB)

Identifiers

PMID35908116
PMCPMC10359372
OpenAlexW4288843939

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.