ArticleNature communications2022
Evaluation of transplacental transfer of mRNA vaccine products and functional antibodies during pregnancy and infancy.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
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Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic review and meta-analysis of neonatal outcomes of COVID-19 vaccination in pregnancy.Pediatric research · 2023Pooled it
- Maternal Antibody Interference and Hybrid Immune Responses to COVID-19 Vaccination in Young Children.Research square · 2026Article
- Maternal vaccination timing shapes the composition and maturation of antibody clonotypes transferred to the newborn.bioRxiv : the preprint server for biology · 2026Article
- Multi-factorial regulatory networks of placental antibody transfer by Fc receptors and maternal IgG Fc characteristics are modulated by clinical covariate profiles.bioRxiv : the preprint server for biology · 2026Article
- Association between maternal anti-Ro and anti-La antibody levels and congenital heart block: a 20-year cohort study.Archives of gynecology and obstetrics · 2026Article
- Detection of spike protein in term placentas of COVID-19 vaccinated and/or SARS-CoV-2 infected women.PloS one · 2026Article
- Pregnancy and lactation induce distinct immune responses to COVID-19 booster vaccination and SARS-CoV-2 breakthrough infection.JCI insight · 2025Article
- A Study of Transplacental Transfer of SARS-CoV-2 Antibodies in COVID-19 Vaccinated Women in Mumbai, India.Cureus · 2025Article
- Enhanced placental antibody transfer efficiency with longer interval between maternal respiratory syncytial virus vaccination and birth.American journal of obstetrics and gynecology · 2025Article
- Cord blood IgA/M reveals in utero response to SARS-CoV-2 with fluctuations in relation to circulating variants.Nature communications · 2025Article
- mRNA-1273 is placenta-permeable and immunogenic in the fetus.Molecular therapy. Nucleic acids · 2025Article
- The association between coronavirus disease 2019 vaccination during pregnancy and neonatal health outcomes.Pediatric investigation · 2025Article
- Post-vaccination SARS-CoV-2 neutralizing antibodies in pregnant women receiving biologics for inflammatory bowel disease.PloS one · 2025Observational
- Assessment of Placental Antioxidant Defense Markers in Vaccinated and Unvaccinated COVID-19 Third-Trimester Pregnancies.Life (Basel, Switzerland) · 2024Article
- COVID-19 Vaccine mRNA Biodistribution: Maternal and Fetal Exposure Risks.American journal of reproductive immunology (New York, N.Y. : 1989) · 2024Review
- Neutralizing and binding antibody responses to SARS-CoV-2 with hybrid immunity in pregnancy.NPJ vaccines · 2024Article
- Influence of Maternal and Neonatal Factors on Transplacental Passive Immunity after Vaccination against COVID-19.Vaccines · 2024Article
- Transplacental transmission of the COVID-19 vaccine messenger RNA: evidence from placental, maternal, and cord blood analyses postvaccination.American journal of obstetrics and gynecology · 2024Article
- Comparison of Anti-SARS-CoV-2-Specific Antibody Signatures in Maternal and Infant Blood after COVID-19 Infection versus COVID-19 Vaccination during Pregnancy.American journal of perinatology · 2024Article
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20 authors.
Funding
Abstract
Studies are needed to evaluate the safety and effectiveness of mRNA SARS-CoV-2 vaccination during pregnancy, and the levels of protection provided to their newborns through placental transfer of antibodies. Here, we evaluate the transplacental transfer of mRNA vaccine products and functional anti-SARS-CoV-2 antibodies during pregnancy and early infancy in a cohort of 20 individuals vaccinated during late pregnancy. We find no evidence of mRNA vaccine products in maternal blood, placenta tissue, or cord blood at delivery. However, we find time-dependent efficient transfer of IgG and neutralizing antibodies to the neonate that persists during early infancy. Additionally, using phage immunoprecipitation sequencing, we find a vaccine-specific signature of SARS-CoV-2 Spike protein epitope binding that is transplacentally transferred during pregnancy. Timing of vaccination during pregnancy is critical to ensure transplacental transfer of protective antibodies during early infancy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.