Evidence map›Paper›PMID 35908050›Full record

ArticleScientific reports2022

Human umbilical cord mesenchymal stem cells derived extracellular vesicles regulate acquired immune response of lupus mouse in vitro.

Min Xie, Cuifang Li, Zhou She, Feifeng Wu, Jueyi Mao, Marady Hun, Senlin Luo, Wuqing Wan, Jidong Tian, Chuan Wen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

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  14. Current cell therapies for systemic lupus erythematosus.Stem cells translational medicine · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Min XieDivision of Hematology and Tumor, Children's Medical Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Cuifang LiDivision of Hematology and Tumor, Children's Medical Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Zhou SheDivision of Hematology and Tumor, Children's Medical Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Feifeng WuDivision of Hematology and Tumor, Children's Medical Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Jueyi MaoDivision of Hematology and Tumor, Children's Medical Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Marady HunDivision of Hematology and Tumor, Children's Medical Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Senlin LuoDivision of Hematology and Tumor, Children's Medical Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Wuqing WanDivision of Hematology and Tumor, Children's Medical Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Jidong TianDivision of Hematology and Tumor, Children's Medical Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Chuan WenDivision of Hematology and Tumor, Children's Medical Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China. chuanwen@csu.edu.cn.
Second Xiangya Hospital of Central South University · CNCentral South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease involving multiple systems. Immunopathology believes that abnormal T cell function and excessive production of autoantibodies by B cells are involved in multi-organ damage. Human umbilical cord mesenchymal stem cells (hUCMSCs) therapies have endowed with promise in SLE, while the function of MSC-derived extracellular vesicles (MSC-EVs) was still unclear. Extracellular vesicles (EVs) are subcellular components secreted by a paracellular mechanism and are essentially a group of nanoparticles. EVs play a vital role in cell-to-cell communication by acting as biological transporters. New evidence has shown beneficial effects of MSC-EVs on autoimmune diseases, such as their immunomodulatory properties. In this study, we investigated whether hUCMSCs derived extracellular vesicles (hUCMSC-EVs) could regulate abnormal immune responses of T cells or B cells in SLE. We isolated splenic mononuclear cells from MRL/lpr mice, a classical animal model of SLE. PBS (Phosphate-buffered saline), 2 × 10

Indexed as

Extracellular VesiclesLupus Erythematosus, SystemicMesenchymal Stem CellsAnimalsHumansImmunityMiceMice, Inbred MRL lprUmbilical Cord

Identifiers

PMID35908050
PMCPMC9338971
OpenAlexW4288758053

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.