ArticleNature communications2022
1,2-Amino oxygenation of alkenes with hydrogen evolution reaction.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Orthogonal nucleophile-ordered assembly for modular access to enantiopure 1,2-amino alcohols.Nature chemistry · 2026Article
- Intermolecular Selective 1,2-Aminohydroxylation of 1,3-Dienes Enabled by Palladium/Copper/Oxygen Cooperation.Precision chemistry · 2026Article
- Copper-Catalyzed Amino-alkoxycarbonylation of Unactivated Alkenes: Synthesis of β-Amino Esters via Primary Tosyl Amidyl Radical.Organic letters · 2026Article
- Three-Component Catalytic Amino Etherification of Alkenes: Enabled by Silyl Ether-Promoted C-O Coupling.ACS catalysis · 2025Article
- The Duality of Dioxolanyl Radicals towards C-C Bond Construction.Synlett : accounts and rapid communications in synthetic organic chemistry · 2025Article
- Unified Hydrogen Atom Transfer Approach To Construct Vicinal Functionality.Organic letters · 2025Article
- Copper-Catalyzed Selective Amino-alkoxycarbonylation of Unactivated Alkenes with CO.Journal of the American Chemical Society · 2025Article
- Beyond Conventional Organic Electrosynthesis: The Role of Fluorinated Solvents.ACS electrochemistry · 2025Review
- Universal high-efficiency electrocatalytic olefin epoxidation via a surface-confined radical promotion.Nature communications · 2024Article
- Electrochemical Palladium-Catalyzed Oxidative Carbonylation-Cyclization of Enallenols.Angewandte Chemie (International ed. in English) · 2022Article
- Engineering Enzyme Substrate Scope Complementarity for Promiscuous Cascade Synthesis of 1,2-Amino Alcohols.Angewandte Chemie (International ed. in English) · 2022Article
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Authors and funding
6 authors.
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Abstract
1,2-Amino oxygenation of alkenes has emerged as one of the most straightforward synthetic methods to produce β-amino alcohols, which are important organic building blocks. Thus, a practical synthetic strategy for 1,2-amino oxygenation is highly desirable. Here, we reported an electro-oxidative intermolecular 1,2-amino oxygenation of alkenes with hydrogen evolution, removing the requirement of extra-oxidant. Using commercial oxygen and nitrogen sources as starting materials, this method provides a cheap, scalable, and efficient route to a set of valuable β-amino alcohol derivatives. Moreover, the merit of this protocol has been exhibited by its broad substrate scope and good application in continuous-flow reactors. Furthermore, this method can be extended to other amino-functionalization of alkenes, thereby showing the potential to inspire advances in applications of electro-induced N-centered radicals (NCRs).
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