Evidence map›Paper›PMID 35908015›Full record

ArticleStem cell research & therapy2022

Intratunical injection of rat-derived bone marrow mesenchymal stem cells prevents fibrosis and is associated with increased Smad7 expression in a rat model of Peyronie's disease.

Wenting Wang, Weifang Ding, Xuebao Zhang, Shuang Wu, Tianxi Yu, Xin Cui, Yaqi Xie, Diandong Yang, Chunhua Lin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research & therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Research Advances in Stem Cell Therapy for Erectile Dysfunction.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2024
    Review
  7. Article
  8. Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Wenting Wang *Central Laboratory, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, 26400, China.
Weifang Ding *Department of Health Care, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, 26400, China.
Xuebao ZhangReproductive Medicine Center, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, 26400, China.
Shuang WuDepartment of Urology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, 26400, China.
Tianxi YuDepartment of Urology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, 26400, China.
Xin CuiDepartment of Urology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, 26400, China.
Yaqi XieDepartment of Urology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, 26400, China.
Diandong YangDepartment of Urology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, 26400, China. yddyhd1970@163.com.
Chunhua LinDepartment of Urology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, 26400, China. urologylch@qdu.edu.cn.ORCID 0000-0001-5225-3518
Qingdao University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivePeyronie's disease (PD) is a fibrotic disorder of the penis, but effective treatments are lacking. Here, we observed the effects of rat-derived bone marrow mesenchymal stem cells (BMSCs) injection in the active phase and chronic phase in a rat model of PD, and the possible mechanism was analysed with fibroblasts derived from rat penile tunica albuginea (TA).

methodsThirty-two male Sprague-Dawley rats were divided into four groups. In sham group, the rats were injected with 50 µL of vehicle. In the PD group, the rats were injected with 50 µg TGF-β1. In the PD + BMSCs early treatment group, the rats were injected with 50 µg TGF-β1 and injected with 1 × 10

resultsErectile function obviously improved, and fibrosis of penile TA was prevented after BMSCs treatment compared with that in the rats with PD. Furthermore, the effects of BMSCs treatment in the active phase were better than those in the chronic phase. After cocultured with BMSCs, cell viability was not affected, Smad7 expression was upregulated, and collagen 3, elastase-2B and osteopontin levels were decreased in the TGF-β1-treated fibroblasts. After transfection with Smad7 siRNA, the antifibrotic effects of BMSCs were offset.

conclusionsThe antifibrotic effects of BMSCs treatment in the active phase of the PD rat model were better than those in the chronic phase. A possible mechanism of BMSCs treatment was related to increased Smad7 expression, suggesting a possible effective and safe procedure for the treatment of PD.

Indexed as

Erectile DysfunctionMesenchymal Stem CellsPenile IndurationAnimalsBone Marrow CellsDisease Models, AnimalFibrosisHumansMaleOsteopontinPancreatic ElastaseRatsRats, Sprague-DawleyRNA, Small InterferingSmad7 ProteinTransforming Growth Factor beta1OsteopontinPancreatic ElastaseRNA, Small InterferingSmad7 ProteinSMAD7 protein, humanSmad7 protein, ratTransforming Growth Factor beta1Bone marrow mesenchymal stem cellsElastase-2BOsteopontinPeyronie’s diseaseSmad7

Identifiers

PMID35908015
PMCPMC9338499
OpenAlexW4288749642

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.