ReviewCancer metastasis reviews2022
The timing of adiposity and changes in the life course on the risk of cancer.
Review in Cancer metastasis reviews, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 25 citations in OpenAlex.
- Shaping the future of early-onset colorectal cancer prevention.Nature reviews. Cancer · 2026Review
- Adiposity and cancer: epidemiology, mechanisms and future perspectives.Nature metabolism · 2026Review
- Weight trajectories throughout adulthood and prostate cancer incidence, aggressiveness, and death in 258 494 men.Journal of the National Cancer Institute · 2026Article
- Disentangling the Effect of BMI on Hepatocellular Carcinoma From Cirrhosis With Multivariable Mendelian Randomization.Liver international : official journal of the International Association for the Study of the Liver · 2026Article
- Lipids grease the chain of cancer progression.Trends in cancer · 2026Review
- European Code Against Cancer, 5th edition - diet, excess body weight, physical activity, sedentary behavior, breastfeeding, and cancer.Molecular oncology · 2026Review
- Adolescent to adulthood weight trajectories and the risk of obesity-related cancers, overall and early-onset: a population-based cohort study.EClinicalMedicine · 2026Article
- Obesity and Early-Stage Breast Cancer: A Comprehensive Analysis of Tumor Biology, Staging Accuracy, and Long-Term Outcomes.Obesity science & practice · 2025Article
- Serum urate levels and colorectal cancer risk: a prospective cohort study in of the UK biobank and a Mendelian randomization analysis.Discover oncology · 2025Article
- Article
- Waist circumference-years and cancer risk: a prospective study of the association and comparison of predictive performance with waist circumference and body mass index.British journal of cancer · 2024Article
- Review
- Overweight-years and cancer risk: A prospective study of the association and comparison of predictive performance with body mass index (Atherosclerosis Risk in Communities Study).International journal of cancer · 2024Article
- Association between urinary phthalates and phthalate metabolites and cancer risk: A systematic review and meta-analysis.Heliyon · 2024Article
- Excess weight, weight gain, and prostate cancer risk and prognosis: the PROCA-life study.Acta oncologica (Stockholm, Sweden) · 2024Article
- Relationship between oily fish intake and breast cancer based on estrogen receptor status: a Mendelian randomization study.Breast cancer research and treatment · 2024Article
- Obesity and prostate cancer screening, incidence, and mortality in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.Journal of the National Cancer Institute · 2023Article
- Integrative bioinformatics analysis to screen key genes and signalling pathways related to ferroptosis in obesity.Adipocyte · 2023Article
- Bidirectional Mendelian randomization analysis of the genetic association between primary lung cancer and colorectal cancer.Journal of translational medicine · 2023Article
- UEG position paper: Obesity and digestive health.United European gastroenterology journal · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Excess body weight has been established as a risk factor for at least twelve cancer sites, though questions remain as to the timing of associations for adiposity and cancer risk throughout the life course. We conducted a narrative review summarizing existing evidence to provide insights into the complex timing relationship between adiposity and risk of seven common obesity-related cancers. We considered five types of studies, including traditional epidemiologic studies examining adiposity at different time points, studies examining weight gain in specific life phases, studies examining weight loss over a period including from bariatric surgery, life course trajectory analysis, and Mendelian randomization studies. The results showed that lifetime excess body weight is associated with increased risk of cancers of endometrium, colorectum, liver, kidney, and pancreas. Early life obesity is one of the strongest risk factors for pancreatic cancer but less directly important than adult obesity for endometrial and kidney cancer. Interestingly, heavy weight during childhood, adolescence, and early adulthood is protective against pre- and postmenopausal breast cancer and possibly advanced prostate cancer. It is apparent that preventing weight gain later in adulthood would likely reduce risk of many cancers, including postmenopausal breast cancer, endometrial cancer, colorectal cancer (especially in men), liver cancer, kidney cancer, and probably advanced prostate cancer. Furthermore, weight loss even late in life may confer benefits for cancers of breast, endometrium, colorectum, and liver among patients with obesity, as mostly demonstrated by studies of bariatric surgery. Overall, maintaining a healthy weight throughout the life course will help prevent a large number of cancers.
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