Evidence map›Paper›PMID 35907835›Full record

ArticleJournal of nanobiotechnology2022

Iron oxide and iron oxyhydroxide nanoparticles impair SARS-CoV-2 infection of cultured cells.

Marta L DeDiego, Yadileiny Portilla, Neus Daviu, Darío López-García, Laura Villamayor, Vladimir Mulens-Arias, Jesús G Ovejero, Álvaro Gallo-Cordova, Sabino Veintemillas-Verdaguer, M Puerto Morales and 1 more

Open access · goldAbstract read
In one paragraph

Article in Journal of nanobiotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Marta L DeDiego *Department of Molecular and Cellular Biology, Centro Nacional de Biotecnología (CNB-CSIC), Darwin 3, 28049, Madrid, Spain. marta.lopez@cnb.csic.es.ORCID http://orcid.org/0000-0002-7888-7372
Yadileiny Portilla *Department of Immunology, Oncology and Nanobiomedicine Initiative, Centro Nacional de Biotecnología (CNB-CSIC), Darwin 3, 28049, Madrid, Spain.ORCID http://orcid.org/0000-0003-2738-0384
Neus DaviuDepartment of Immunology, Oncology and Nanobiomedicine Initiative, Centro Nacional de Biotecnología (CNB-CSIC), Darwin 3, 28049, Madrid, Spain.ORCID http://orcid.org/0000-0002-1255-2481
Darío López-GarcíaDepartment of Molecular and Cellular Biology, Centro Nacional de Biotecnología (CNB-CSIC), Darwin 3, 28049, Madrid, Spain.ORCID http://orcid.org/0000-0002-5990-8940
Laura VillamayorDepartment of Molecular and Cellular Biology, Centro Nacional de Biotecnología (CNB-CSIC), Darwin 3, 28049, Madrid, Spain.ORCID http://orcid.org/0000-0002-2264-5059
Vladimir Mulens-AriasDepartment of Immunology, Oncology and Nanobiomedicine Initiative, Centro Nacional de Biotecnología (CNB-CSIC), Darwin 3, 28049, Madrid, Spain.ORCID http://orcid.org/0000-0003-3637-3039
Jesús G OvejeroDepartment of Energy, Environment and Health, Instituto de Ciencia de Materiales de Madrid (ICMM-CSIC), Sor Juana Inés de la Cruz 3, 28049, Madrid, Spain.ORCID http://orcid.org/0000-0003-3774-6589
Álvaro Gallo-CordovaDepartment of Energy, Environment and Health, Instituto de Ciencia de Materiales de Madrid (ICMM-CSIC), Sor Juana Inés de la Cruz 3, 28049, Madrid, Spain.ORCID http://orcid.org/0000-0001-5140-9162
Sabino Veintemillas-VerdaguerDepartment of Energy, Environment and Health, Instituto de Ciencia de Materiales de Madrid (ICMM-CSIC), Sor Juana Inés de la Cruz 3, 28049, Madrid, Spain.ORCID http://orcid.org/0000-0002-3015-1470
M Puerto MoralesDepartment of Energy, Environment and Health, Instituto de Ciencia de Materiales de Madrid (ICMM-CSIC), Sor Juana Inés de la Cruz 3, 28049, Madrid, Spain. puerto@icmm.csic.es.ORCID http://orcid.org/0000-0002-7290-7029
Domingo F BarberDepartment of Immunology, Oncology and Nanobiomedicine Initiative, Centro Nacional de Biotecnología (CNB-CSIC), Darwin 3, 28049, Madrid, Spain. dfbarber@cnb.csic.es.ORCID http://orcid.org/0000-0001-8824-5405
Centro Nacional de Biotecnología · ESInstituto de Ciencia de Materiales de Madrid · ESHospital General Universitario Gregorio Marañón · ESInstituto de Investigaciones Biomédicas Sols-Morreale · ESUniversitat Pompeu Fabra · ES

Funding

"Atracción de Talento Investigador" programme , Comunidad de Madrid 2017-T1/BMD-5155European Commission-NextGenerationEU (Regulation EU2020/2094) through CSIC's Global Health Platform (PTI Salud Global) SGL2103021MCIN/AEI/10.13039/501100011033 PID2020-112685RB-100MCIN/AEI/10.13039/501100011033 and by "ESF Investing in your future" predoctoral FPU scholar FPU15/06170MCIN/AEI/10.13039/501100011033 and by "ESF Investing in your future", predoctoral FPU scholar FPU18/04828MCIN/AEI/10.13039/501100011033 and by the "European Union NextGenerationEU/PRTR PDC2021-120759-100MCIN/AEI/10.13039/501100011033, Juan de La Cierva-Incorporación Contract IJCI-2017-31447Spanish National Research Council Interdisciplinary Thematic Platform (PTI) Global Health (PTI Salud Global) CSIC-COV19-012/012202020E154Spanish National Research Council JAE-INTRO 2020 Fellowship JAEINT-20-01805
6 · The paper itself

Abstract

backgroundCoronaviruses usually cause mild respiratory disease in humans but as seen recently, some human coronaviruses can cause more severe diseases, such as the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the global spread of which has resulted in the ongoing coronavirus pandemic.

resultsIn this study we analyzed the potential of using iron oxide nanoparticles (IONPs) coated with biocompatible molecules like dimercaptosuccinic acid (DMSA), 3-aminopropyl triethoxysilane (APS) or carboxydextran (FeraSpin™ R), as well as iron oxyhydroxide nanoparticles (IOHNPs) coated with sucrose (Venofer

conclusionsTherefore, our results suggest that IONPs and IOHNPs may be repurposed to be used as prophylactic or therapeutic treatments in order to combat SARS-CoV-2 infection.

Indexed as

COVID-19 Drug TreatmentNanoparticlesAnimalsCells, CulturedFerric CompoundsFerric Oxide, SaccharatedHumansIronMiceSARS-CoV-2Ferric Compoundsferric hydroxideferric oxideFerric Oxide, SaccharatedIronAnti-anemicIron metabolismIron oxide nanoparticlesIron oxyhydroxide nanoparticlesMRI contrast agentsOxidative stressSARS-CoV-2Viral infectionViral replication

Identifiers

PMID35907835
PMCPMC9338509
OpenAlexW4288685407

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.