Evidence map›Paper›PMID 35907822›Full record

ArticleBMC public health2022

The global burden and associated factors of ovarian cancer in 1990-2019: findings from the Global Burden of Disease Study 2019.

Shiwen Zhang, Chen Cheng, Zejian Lin, Linzi Xiao, Xin Su, Lu Zheng, Yingjun Mu, Minqi Liao, Ruiqing Ouyang, Wanlin Li and 6 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06253559 (Clinical and Pathological Characteristics of Women With Ovarian Cancers, A National, Retrospective Cross-Sectional Study in Syria During the War), which is not on this map. Cited by 50 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06253559 completednot on this map

Clinical and Pathological Characteristics of Women With Ovarian Cancers, A National, Retrospective Cross-Sectional Study in Syria During the War

TypeobservationalSponsorLatakia UniversityRan2017 to 2023Enrolled531ConditionsOvarian Cancer
3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  14. Environment, lifestyle, and cancer in women.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Shiwen Zhang *Department of Public Health and Preventive , of Medicine, Jinan University, Guangzhou, China.
Chen Cheng *Department of Public Health and Preventive , of Medicine, Jinan University, Guangzhou, China.
Zejian LinDepartment of Public Health and Preventive , of Medicine, Jinan University, Guangzhou, China.
Linzi XiaoDepartment of Public Health and Preventive , of Medicine, Jinan University, Guangzhou, China.
Xin SuDepartment of Public Health and Preventive , of Medicine, Jinan University, Guangzhou, China.
Lu ZhengDepartment of Public Health and Preventive , of Medicine, Jinan University, Guangzhou, China.
Yingjun MuDepartment of Public Health and Preventive , of Medicine, Jinan University, Guangzhou, China.
Minqi LiaoDepartment of Public Health and Preventive , of Medicine, Jinan University, Guangzhou, China.
Ruiqing OuyangDepartment of Public Health and Preventive , of Medicine, Jinan University, Guangzhou, China.
Wanlin LiDepartment of Public Health and Preventive , of Medicine, Jinan University, Guangzhou, China.
Junrong MaDepartment of Public Health and Preventive , of Medicine, Jinan University, Guangzhou, China.
Jun CaiDepartment of Public Health and Preventive , of Medicine, Jinan University, Guangzhou, China.
Lu LiuDepartment of Preventive Medicine Laboratory, School of Public Health, Zunyi Medical University, Zunyi, China.
Donghong WangDepartment of Gynaecology and Obstetrics, Affiliated Hospital of Zunyi Medical University, Guizhou, China.
Fangfang ZengDepartment of Public Health and Preventive , of Medicine, Jinan University, Guangzhou, China. zengffjnu@126.com.
Jun LiuDepartment of Preventive Medicine Laboratory, School of Public Health, Zunyi Medical University, Zunyi, China. liujun_zmc@sina.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOvarian cancer (OC) is a major cause of cancer-related deaths among women. The aim of this study was to estimate and report data on the current burden of ovarian cancer worldwide over the past 30 years.

methodBased on the data provided by GBD 2019, we collected and interpreted the disease data of ovarian cancer by incidence, mortality, disability-adjusted life-years (DALYs), and used corresponding age-standardized rates as indicators. Also, we categorized the data by attributed risk factors and captured deaths due to high fasting plasma glucose, occupational exposure to asbestos and high body-mass index, respectively. All outcomes in the study were reported using mean values and corresponding 95% uncertainty intervals (95% UI).

resultsGlobally, there were 294422 (260649 to 329727) incident cases in 2019, and the number of deaths and DALYs were 198412 (175357 to 217665) and 5.36 million (4.69 to 5.95). The overall burden was on the rise, with a percentage change of 107.8% (76.1 to 135.7%) for new cases, 103.8% (75.7 to 126.4%) for deaths and 96.1% (65.0 to 120.5%) for DALYs. Whereas the age-standardized rates kept stable during 1990-2019. The burden of ovarian cancer increased with age. and showed a totally different trends among SDI regions. Although high SDI region had the declining rates, the burden of ovarian cancer remained stable in high-middle and low SDI regions, and the middle and low-middle SDI areas showed increasing trends. High fasting plasma glucose was estimated to be the most important attributable risk factor for ovarian cancer deaths globally, with a percentage change of deaths of 7.9% (1.6 to 18.3%), followed by occupational exposure to asbestos and high body mass index.

conclusionsAlthough the age-standardized rates of ovarian cancer didn't significantly change at the global level, the burden still increased, especially in areas on the lower end of the SDI range. Also, the disease burden due to different attributable risk factors showed heterogeneous, and it became more severe with age.

Indexed as

Global Burden of DiseaseOvarian NeoplasmsBlood GlucoseFemaleGlobal HealthHumansIncidenceQuality-Adjusted Life YearsRisk FactorsBlood GlucoseGlobal burden of disease study 2019Ovarian cancerRisk factors

Identifiers

PMID35907822
PMCPMC9339194

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.