Evidence map›Paper›PMID 35907808›Full record

ArticleBMC musculoskeletal disorders2022

The potential performance of serum albumin to globulin ratio, albumin and globulin in the diagnosis of periprosthetic joint infection and prediction of reinfection following reimplantation.

Haitao Zhang, Shuihua Xie, YiJin Li, Jiahao Li, Peng Deng, Huiliang Zeng, Houran Cao, Min Liu, Jie Li, Wenjun Feng and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC musculoskeletal disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Role of Biomarkers in Periprosthetic Joint Infections.Diagnostics (Basel, Switzerland) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Haitao Zhang *The First Clinical of Medical School, Guangzhou University of Chinese Medicine, NO.12 Jichang Road, District Baiyun, Guangzhou, 510405, Guangdong, China.
Shuihua Xie *The First Department of Orthopedics, Jiangxi Province Hospital of Integrated Chinese and Western Medicine, NO.90 Bayi Road, District Xihu, Nanchang, 330003, Jiangxi, China. xieshuihua6601@163.com.
YiJin LiThe First Clinical of Medical School, Guangzhou University of Chinese Medicine, NO.12 Jichang Road, District Baiyun, Guangzhou, 510405, Guangdong, China.
Jiahao LiThe First Clinical of Medical School, Guangzhou University of Chinese Medicine, NO.12 Jichang Road, District Baiyun, Guangzhou, 510405, Guangdong, China.
Peng DengDepartment of Orthopaedics, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, NO.16 Jichang Road, District Baiyun, Guangzhou, 510405, Guangdong, China.
Huiliang ZengThe Tenth Department of Orthopedics, Foshan Hospital of Chinese Medicine, NO.6 Qinren Road, District Chancheng, Foshan, 528000, Guangdong, China.
Houran CaoThe Director of the Orthopedic Department of, Guangdong Province Hospital of Traditional Chinese Medicine, NO.111 Dade Road, District Yuexiu, Guangzhou, 510000, Guangdong, China.
Min LiuThe Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, No.445 Bayi Avenue, Nanchang, 330000, Jiangxi, China.
Jie LiDepartment of Orthopaedics, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, NO.16 Jichang Road, District Baiyun, Guangzhou, 510405, Guangdong, China.
Wenjun FengDepartment of Orthopaedics, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, NO.16 Jichang Road, District Baiyun, Guangzhou, 510405, Guangdong, China.
Pengcheng YeDepartment of Orthopaedics, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, NO.16 Jichang Road, District Baiyun, Guangzhou, 510405, Guangdong, China.
Yingjie GeThe First Clinical of Medical School, Guangzhou University of Chinese Medicine, NO.12 Jichang Road, District Baiyun, Guangzhou, 510405, Guangdong, China.
Jianchun ZengDepartment of Orthopaedics, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, NO.16 Jichang Road, District Baiyun, Guangzhou, 510405, Guangdong, China.
Yirong ZengDepartment of Orthopaedics, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, NO.16 Jichang Road, District Baiyun, Guangzhou, 510405, Guangdong, China. zeng1966zeng@126.com.
First Affiliated Hospital of Guangzhou University of Chinese Medicine · CNGuangzhou University of Chinese Medicine · CNAffiliated Hospital of Jiangxi University of Traditional Chinese Medicine · CNFoshan Hospital of TCM · CNGuangdong Provincial Hospital of Traditional Chinese Medicine · CNIntegrated Chinese Medicine (China) · CN

Funding

the High-Level Hospital Construction Project of the First Affiliated Hospital of Guangzhou University of Chinese Medicine 211010010722
6 · The paper itself

Abstract

backgroundThis study was conducted to evaluate the performance of serum albumin (ALB), globulin (GLO), and albumin to globulin ratio (AGR) in the diagnosis of PJI and prediction of reinfection following reimplantation in PJI patients who underwent two-stage revision.

methodsWe perform a retrospective data collection on identified patients who underwent revision arthroplasties in our institution from January 2010 to January 2020. A total of 241 patients were stratified into: group A (PJI), group B (aseptic loosening). Fifty-five patients who underwent two-stage revision in group A were assigned to group C. Group C was stratified into subgroup 1 (reinfection) and subgroup 2 (non-reinfection). Receiver operating characteristic curves were used to evaluate the utility of serum markers for diagnosing PJI and predicting reinfection following reimplantation.

resultsIn the diagnosis of PJI, there were significant differences in the levels of ALB, GLO, and AGR between groups A and group B (P < 0.05). The AUC value of serum AGR (0.851) was similar to ESR (0.841) and CRP (0.866) (all p > 0.05). The AUC values of serum ALB and GLO were 0.757 and 0.753, respectively. As for predicting reinfection following reimplantation, the serum ALB in the non-reinfection group was higher than that in the reinfection group (p = 0.041). The AUC value of serum ALB was 0.7.

conclusionAGR was promising adjunct marker for the diagnosis of PJI, similar to CRP and ESR. ALB and GLO have an acceptable value for the diagnosis of PJI. ALB may be expected to be a kind of effective marker for predicting reinfection following reimplantation.

Indexed as

Arthritis, InfectiousArthroplasty, Replacement, HipGlobulinsProsthesis-Related InfectionsBiomarkersBlood SedimentationC-Reactive ProteinHumansReoperationReplantationRetrospective StudiesSerum AlbuminBiomarkersC-Reactive ProteinGlobulinsSerum AlbuminDiagnosisPerformancePeriprosthetic joint infectionReimplantationSerum albumin to globulin ratio

Identifiers

PMID35907808
PMCPMC9338558
OpenAlexW4288685134

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.