ArticleBMC infectious diseases2022
Multi-marker approach using C-reactive protein, procalcitonin, neutrophil CD64 index for the prognosis of sepsis in intensive care unit: a retrospective cohort study.
Article in BMC infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Diagnostic Performance and Prognostic Value of Serum Amyloid A in Patients with Bloodstream Infection.Diagnostics (Basel, Switzerland) · 2026Article
- Serum CD73 activity as a biomarker of hypoxemia in COVID-19 patients.Scientific reports · 2026Article
- Evaluation of the clinical value of serum inflammatory mediators in assessing sepsis severity.Pakistan journal of medical sciences · 2026Article
- Clinical Value of Galectin-9, Soluble TREM-1, and Soluble CD25 Among Critically Ill Patients with Organ Failure in the Emergency Department: A Prospective Observational Study.Diagnostics (Basel, Switzerland) · 2025Article
- Inflammatory burden index as a predictor of mortality in septic patients: a retrospective study using the MIMIC-IV database.BMC infectious diseases · 2025Article
- Prognostic value of NPR and CLR-based nomogram modeling in elderly patients with Acinetobacter baumannii bloodstream infection.BMC geriatrics · 2025Article
- Article
- Optical Bionanosensors for Sepsis Diagnostics.Small (Weinheim an der Bergstrasse, Germany) · 2025Review
- Neutrophil CD64 index: a novel biomarker for risk stratification in acute pancreatitis.Frontiers in immunology · 2025Article
- Factors predicting discharge outcomes of sepsis patients admitted to intensive care unit in a major tertiary care hospital: A retrospective study from Palestine.PLOS global public health · 2025Article
- Article
- Sepsis Biomarkers: Advancements and Clinical Applications-A Narrative Review.International journal of molecular sciences · 2024Review
- Serial Trend of Neutrophil CD64, C-reactive Protein, and Procalcitonin as a Prognostic Marker in Critically Ill Patients with Sepsis/Septic Shock: A Prospective Observational Study from a Tertiary Care ICU.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2024Article
- Neutrophil CD64 index as a new early predictive biomarker for infected pancreatic necrosis in acute pancreatitis.Journal of translational medicine · 2024Article
- The value of lymphocyte-to-C-reactive protein ratio for predicting clinical outcomes in patients with sepsis in intensive care unit: a retrospective single-center study.Frontiers in molecular biosciences · 2024Article
- Diagnostic role of CD64 expression on neutrophils as biomarker for blood stream infection in liver cirrhosis: some preliminary findings.Le infezioni in medicina · 2024Article
- Clinical predictive value of the CRP-albumin-lymphocyte index for prognosis of critically ill patients with sepsis in intensive care unit: a retrospective single-center observational study.Frontiers in public health · 2024Observational
- Neutrophil CD64-a prognostic marker of sepsis in intensive care unit: a prospective cohort study.Frontiers in medicine · 2023Article
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8 authors.
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Abstract
backgroundWe aimed to explore the prognostic utilities of C-reactive protein (CRP), procalcitonin (PCT), neutrophil CD64 (nCD64) index, in combination or alone, in septic patients.
methodsWe retrospectively included 349 septic patients (based on Sepsis 3.0 definition). The primary outcome was 28-day all-cause mortality. Cox regression model, receiver-operating characteristic (ROC) curve, reclassification analysis, Kaplan-Meier survival curves were performed to evaluate the predictive efficacy of the above parameters.
resultsCRP, nCD64 index were independent predictors of 28-day mortality for sepsis in the Cox regression model [CRP, HR 1.004 (95% CI 1.002-1.006), P < 0.001; nCD64 index, HR 1.263 (95% CI 1.187-1.345, P < 0.001]. Area under the ROC curve (AUC) of CRP, PCT, nCD64 index, nCD64 index plus PCT, nCD64 index plus CRP, were 0.798 (95% CI 0.752-0.839), 0.833 (95% CI 0.790-0.871), 0.906 (95% CI 0.870-0.935), 0.910 (95% CI 0.875-0.938), 0.916 (95% CI 0.881-0.943), respectively. nCD64 plus CRP performed best in prediction, discrimination, and reclassification of the 28-day mortality risk in sepsis. The risk of 28-day mortality increased stepwise as the number of data exceeding optimal cut-off values increased.
conclusionsnCD64 index combined with CRP was superior to CRP, PCT, nCD64 index and nCD64 index plus PCT in predicting 28-day mortality in sepsis. Multi-marker approach could improve the predictive accuracy and be beneficial for septic patients.
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