Evidence map›Paper›PMID 35907259›Full record

ArticleThe Journal of clinical endocrinology and metabolism2022

Kidney Complications and Hospitalization in Patients With Chronic Hypoparathyroidism: A Cohort Study in Sweden.

Oskar Swartling, Marie Evans, Tim Spelman, Wafa Kamal, Olle Kämpe, Michael Mannstadt, Ylva Trolle Lagerros, Sigridur Björnsdottir

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Oskar SwartlingDepartment of Medicine, Clinical Epidemiology Division, Karolinska Institutet, Stockholm 171 77, Sweden.ORCID 0000-0002-3783-1567
Marie EvansRenal unit, Department of Clinical Sciences, Interventions and Technology (CLINTEC), Karolinska Institutet and Karolinska University Hospital, Stockholm 141 52, Sweden.ORCID 0000-0001-8650-5795
Tim SpelmanDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm 171 77, Sweden.
Wafa KamalDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm 171 76, Sweden.
Olle KämpeDepartment of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, Stockholm 171 76, Sweden.ORCID 0000-0001-6091-9914
Michael MannstadtEndocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Ylva Trolle LagerrosDepartment of Medicine, Clinical Epidemiology Division, Karolinska Institutet, Stockholm 171 77, Sweden.ORCID 0000-0001-6816-7577
Sigridur BjörnsdottirDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm 171 76, Sweden.
Karolinska University Hospital · SEKarolinska Institutet · SEHarvard University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextKidney complications may be considerably higher in patients with chronic hypoparathyroidism (hypoPT) treated with activated vitamin D and calcium supplementation.

objectiveWe aimed to investigate the risk of chronic kidney disease (CKD), urolithiasis, and hospitalization in patients with chronic hypoPT.

methodsIn this population-based cohort study in Sweden, national registries (Swedish National Patient Register, Swedish Prescribed Drug Register, and Total Population Register, 1997-2018) were used to identify patients with chronic hypoPT and controls matched by sex, age, and county of residence. We determined time to CKD and urolithiasis diagnosis, and incidence rates of hospitalization.

resultsA total of 1562 patients with chronic hypoPT without preexisting CKD and 15 620 controls were included. The risk of developing CKD was higher in patients with chronic hypoPT compared with controls (hazard ratio [HR] 4.45; 95% CI, 3.66-5.41). In people without prior urolithiasis (n = 1810 chronic hypoPT and n = 18 100 controls), the risk of developing urolithiasis was higher in patients with chronic hypoPT (HR 3.55; 95% CI, 2.84-4.44) compared with controls. Patients with chronic hypoPT had higher incidence rates for all-cause hospitalization (49.59; 95% CI, 48.50-50.70, per 100 person-years vs 28.43; 95% CI, 28.15-28.71, respectively) and for CKD (3.46; 95% CI, 3.18-3.76, per 100 person-years vs 0.72; 95% CI, 0.68-0.77, respectively), compared with controls. Men with hypoPT appear to have a higher risk of CKD than women.

conclusionPatients with chronic hypoPT had an increased risk of CKD, urolithiasis, and hospitalization compared with controls.

Indexed as

HypoparathyroidismRenal Insufficiency, ChronicUrolithiasisCalciumCohort StudiesFemaleHospitalizationHumansKidneyMaleSwedenVitamin DCalciumVitamin Dchronic kidney diseaseepidemiologyhypoparathyroidismurolithiasis

Identifiers

PMID35907259
PMCPMC9516192
OpenAlexW4288855695

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.