ArticleThe Journal of clinical endocrinology and metabolism2022
Associations of Serum Vitamin B6 Status and Catabolism With All-Cause Mortality in Patients With T2DM.
Article in The Journal of clinical endocrinology and metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Association between serum vitamin BThe British journal of nutrition · 2026Article
- Nutrient Clusters Associated with the Dietary Inflammatory Index in Patients with Diabetes and Prediabetes: A Prospective Observational Study.Nutrients · 2026Observational
- Age- and sex-specific reference intervals and determinants of plasma vitamin B6 metabolites in healthy Chinese adults.Frontiers in nutrition · 2026Article
- Relationship of Low Vitamin B6 Status with Sarcopenia, Frailty, and Mortality: A Narrative Review.Nutrients · 2024Review
- Mediation of endothelial activation and stress index in the association between vitamin BFrontiers in nutrition · 2024Article
- Associations of serum vitamin B6 status with the risks of cardiovascular, cancer, and all-cause mortality in the elderly.Frontiers in immunology · 2024Article
- Quantification of the Relationship of Pyridoxine and Spirometry Measurements in the United States Population.Current developments in nutrition · 2023Article
- Characterization of gut microbial and metabolite alterations in faeces of Goto Kakizaki rats using metagenomic and untargeted metabolomic approach.World journal of diabetes · 2023Article
- Pretreatment withFrontiers in microbiology · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextThere is little evidence regarding the association between serum vitamin B6 status and catabolism and all-cause mortality in patients with type-2 diabetes mellitus (T2DM).
objectiveWe aimed to ascertain if the serum level of vitamin B6 and catabolism, including pyridoxal 5'-phosphate (PLP) and 4-pyridoxic acid (4-PA), were associated with risk of all-cause mortality in T2DM patients.
methodsThis prospective cohort study involved 2574 patients with T2DM who participated in the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2010. The serum concentrations of PLP and 4-PA were used to assess the serum level of vitamin B6. Mortality status was determined by routine follow-up using the National Death Index through December 31, 2015.
resultsOver a median follow-up of 85 months, there were 588 deaths. The fully adjusted Cox model indicated that the highest serum PLP concentrations (> 63.6 nmol/L) were associated with a decrease in all-cause mortality (hazard ratio [HR], 0.74; 95% CI, 0.55-0.99, P trend = .035). The risk for all-cause mortality was 59% higher for participants with the highest quartile of 4-PA level compared with the lowest quartile (HR, 1.62; 95% CI, 1.12-2.35; P trend = .003). The sensitivity and specificity of the combination of PLP and 4-PA levels for the prediction of all-cause mortality were 59.5% and 60.9%, respectively (area under the receiver operating characteristic curve = 0.632). The Kaplan-Meier method was used to estimate overall survival for patients based on different combinations of PLP level and 4-PA level. Patients with PLP less than 24.3 nmol/L and 4-PA greater than or equal to 25.4 nmol/L had the worst outcomes (log-rank P < .001).
conclusionOverall, our data suggest that a low serum level of PLP and high serum level of 4-PA, which represent the serum level of vitamin B6, increases the risk of all-cause mortality significantly in patients with T2DM.
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