Evidence map›Paper›PMID 35907163›Full record

ArticleDermatology and therapy2022

Randomized Clinical Trial of Conventional versus Indoor Daylight Photodynamic Therapy for Treatment of Actinic Cheilitis.

Mariachiara Arisi, Benedetta Galli, Edoardo Guasco Pisani, Giuseppe La Rosa, Gaetano Licata, Sara Rovaris, Cesare Tomasi, Mariateresa Rossi, Marina Venturini, Luigi Spiazzi and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Dermatology and therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Mariachiara ArisiDermatology Department, University of Brescia, ASST Spedali Civili di Brescia, P. Le Spedali Civili 1, 25123, Brescia, Italy. mariachiara.arisi@gmail.com.ORCID http://orcid.org/0000-0001-6307-6174
Benedetta GalliDermatology Department, University of Brescia, ASST Spedali Civili di Brescia, P. Le Spedali Civili 1, 25123, Brescia, Italy.
Edoardo Guasco PisaniDermatology Department, University of Brescia, ASST Spedali Civili di Brescia, P. Le Spedali Civili 1, 25123, Brescia, Italy.
Giuseppe La RosaDermatology Department, University of Brescia, ASST Spedali Civili di Brescia, P. Le Spedali Civili 1, 25123, Brescia, Italy.
Gaetano LicataDermatology Department, University of Brescia, ASST Spedali Civili di Brescia, P. Le Spedali Civili 1, 25123, Brescia, Italy.
Sara RovarisDermatology Department, University of Brescia, ASST Spedali Civili di Brescia, P. Le Spedali Civili 1, 25123, Brescia, Italy.
Cesare TomasiDermatology Department, University of Brescia, ASST Spedali Civili di Brescia, P. Le Spedali Civili 1, 25123, Brescia, Italy.
Mariateresa RossiDermatology Department, University of Brescia, ASST Spedali Civili di Brescia, P. Le Spedali Civili 1, 25123, Brescia, Italy.
Marina VenturiniDermatology Department, University of Brescia, ASST Spedali Civili di Brescia, P. Le Spedali Civili 1, 25123, Brescia, Italy.
Luigi SpiazziMedical Physics Department, ASST Spedali Civili di Brescia, Brescia, Italy.
PierGiacomo Calzavara-PintonDermatology Department, University of Brescia, ASST Spedali Civili di Brescia, P. Le Spedali Civili 1, 25123, Brescia, Italy.
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionActinic cheilitis (AC) is the biologic precursor of invasive squamous cell carcinoma (SCC) of the vermilion, and different treatment options have been investigated, but their efficacy is hampered by local inflammation, pain and slow recovery. Daylight photodynamic therapy (dl-PDT) has been demonstrated to represent a valuable treatment option for AC, but its feasibility is limited by weather conditions and latitude.

methodsOur study proposed to compare the efficacy and tolerability of conventional photodynamic therapy (c-PDT) and indoor daylight photodynamic therapy (idl-PDT) with a white LED lamp for the treatment of AC. Sixteen patients were enrolled in the study: 8 (50%) treated with c-PDT and 8 (50%) treated with idl-PDT. All patients completed the study protocol.

resultsBoth idl-PDT and c-PDT were demonstrated to be highly effective in terms of reduction of the cumulative lesional area and severity of the clinical score. Neither treatment was inferior to the other. The inflammatory reaction and the pain scores were milder with idl-PDT, whereas the cosmetic outcome was not different.

conclusionThe present findings confirm that idl-PDT can represent a valid therapeutic strategy for AC patients as well, despite the procedural difficulties and the risk of poor tolerability related to the body site.

Indexed as

Actinic cheilitisConventional photodynamic therapyDaylight photodynamic therapyIndoor daylight photodynamic therapyPhotodynamic therapy

Identifiers

PMID35907163
PMCPMC9464288
OpenAlexW4288801940

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.