Evidence map›Paper›PMID 35907138›Full record

ArticleHuman cell2022

Circular RNA circPBX3 promotes cisplatin resistance of ovarian cancer cells via interacting with IGF2BP2 to stabilize ATP7A mRNA expression.

Lihua Fu, Dan Zhang, Nuo Yi, Yanjun Cao, Yaxian Wei, Wenjing Wang, Li Li

Abstract read
PubMed Publisher
In one paragraph

Article in Human cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. IGF2BP2: an mCellular & molecular biology letters · 2025
    Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. Review
  19. RNA binding proteins in cancer chemotherapeutic drug resistance.Frontiers in cell and developmental biology · 2024
    Review
  20. Novel insights into cuproptosis inducers and inhibitors.Frontiers in molecular biosciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lihua FuDepartment of Obstetrics and Gynecology, Beijing Ditan Hospital, Capital Medical University, No. 8 Jingshun East Street, Chaoyang, Beijing, 100015, China.
Dan ZhangDepartment of Obstetrics and Gynecology, Shenyang Women's and Children's Hospital, Shenyang, 110011, China.
Nuo YiDepartment of Obstetrics and Gynecology, Beijing Ditan Hospital, Capital Medical University, No. 8 Jingshun East Street, Chaoyang, Beijing, 100015, China.
Yanjun CaoDepartment of Obstetrics and Gynecology, Beijing Ditan Hospital, Capital Medical University, No. 8 Jingshun East Street, Chaoyang, Beijing, 100015, China.
Yaxian WeiDepartment of Obstetrics and Gynecology, Beijing Ditan Hospital, Capital Medical University, No. 8 Jingshun East Street, Chaoyang, Beijing, 100015, China.
Wenjing WangDepartment of Obstetrics and Gynecology, Beijing Ditan Hospital, Capital Medical University, No. 8 Jingshun East Street, Chaoyang, Beijing, 100015, China.
Li LiDepartment of Obstetrics and Gynecology, Beijing Ditan Hospital, Capital Medical University, No. 8 Jingshun East Street, Chaoyang, Beijing, 100015, China. liliditan@126.com.ORCID http://orcid.org/0000-0001-5903-8183

Funding

Wu Jieping Medical Gene Association clinical research fund 320-6750-17035
6 · The paper itself

Abstract

Circular RNAs (circRNAs) are a class of non-coding RNAs with a unique covalently closed loop structure. Recent studies indicate that dysregulation of circRNAs acts a role in cancer progression and chemotherapy resistance via interacting with RNA-binding proteins (RBPs). Herein, we identified circPBX3 to be involved in cisplatin resistance of ovarian cancer. In our study, two cisplatin-resistant ovarian cancer cell lines were established, and transcriptome RNA-sequencing was performed and circPBX3 was identified as significantly upregulated circRNA in these cells. The characteristics of circPBX3 and potential function of circPBX3 were evaluated. We found that circPBX3 was upregulated in ovarian tumor tissues and cisplatin-resistant ovarian cancer cells. CircPBX3 overexpression increased the half maximal inhibitory rate (IC

Indexed as

Antineoplastic AgentsOvarian NeoplasmsCell Line, TumorCisplatinCopper-Transporting ATPasesDrug Resistance, NeoplasmFemaleGene Expression Regulation, NeoplasticHumansPeptide FragmentsRNA-Binding ProteinsRNA, CircularRNA, MessengerAntineoplastic AgentsATP7A protein, humanATP7A protein, human (2-79)CisplatinCopper-Transporting ATPasesIGF2BP2 protein, humanPeptide FragmentsRNA-Binding ProteinsRNA, CircularRNA, MessengerATP7AcircPBX3Cisplatin resistanceIGF2BP2Ovarian cancer

Identifiers

PMID35907138

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.