Evidence map›Paper›PMID 35907131›Full record

ArticleMetabolic brain disease2022

Pseudoephedrine hydrochloride causes hyperactivity in zebrafish via modulation of the serotonin pathway.

Yini Zhou, Tonglaga Li, Shangzi Zhou, Han Xu, Xiaoyu Yin, Hao Chen, Xuan Ni, Meirong Bai, Wuliji Ao, Jingfeng Yang and 6 more

Abstract read
PubMed Publisher
In one paragraph

Article in Metabolic brain disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 3 countries.

Yini Zhou *Inner Mongolia Key Laboratory of Toxicant Monitoring and Toxicology, College of Animal Science and Technology, Inner Mongolia Minzu University, 028000, Tongliao, Inner Mongolia, China.
Tonglaga Li *Affiliated Hospital of Inner Mongolia Minzu University, 028000, Tongliao, China.
Shangzi ZhouInner Mongolia Key Laboratory of Toxicant Monitoring and Toxicology, College of Animal Science and Technology, Inner Mongolia Minzu University, 028000, Tongliao, Inner Mongolia, China.
Han XuInner Mongolia Key Laboratory of Toxicant Monitoring and Toxicology, College of Animal Science and Technology, Inner Mongolia Minzu University, 028000, Tongliao, Inner Mongolia, China.
Xiaoyu YinInner Mongolia Key Laboratory of Toxicant Monitoring and Toxicology, College of Animal Science and Technology, Inner Mongolia Minzu University, 028000, Tongliao, Inner Mongolia, China.
Hao ChenInner Mongolia Key Laboratory of Toxicant Monitoring and Toxicology, College of Animal Science and Technology, Inner Mongolia Minzu University, 028000, Tongliao, Inner Mongolia, China.
Xuan NiInner Mongolia Key Laboratory of Toxicant Monitoring and Toxicology, College of Animal Science and Technology, Inner Mongolia Minzu University, 028000, Tongliao, Inner Mongolia, China.
Meirong BaiCollege of Mongolian Medicine and Pharmacy, Inner Mongolia Minzu University, 028000, Tongliao, China.
Wuliji AoCollege of Mongolian Medicine and Pharmacy, Inner Mongolia Minzu University, 028000, Tongliao, China.
Jingfeng YangInner Mongolia Key Laboratory of Toxicant Monitoring and Toxicology, College of Animal Science and Technology, Inner Mongolia Minzu University, 028000, Tongliao, Inner Mongolia, China.
R G AhmedDivision of Anatomy and Embryology, Zoology Department, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt.
Xuefu ZhangThe Medical College of Inner Mongolia Minzu University, 028000, Tongliao, Inner Mongolia, China.
Shuyin BaoThe Medical College of Inner Mongolia Minzu University, 028000, Tongliao, Inner Mongolia, China.
Jianhua YuInner Mongolia Key Laboratory of Toxicant Monitoring and Toxicology, College of Animal Science and Technology, Inner Mongolia Minzu University, 028000, Tongliao, Inner Mongolia, China. yjhyjh926@163.com.
Kevin W H KwokDepartment of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Hong Kong. kwh.kwok@polyu.edu.hk.
Wu DongInner Mongolia Key Laboratory of Toxicant Monitoring and Toxicology, College of Animal Science and Technology, Inner Mongolia Minzu University, 028000, Tongliao, Inner Mongolia, China. dongwu@imun.edu.com.ORCID http://orcid.org/0000-0002-2372-2415
Minzu University of China · CNInner Mongolia University for Nationalities · CNBeni-Suef University · EGHong Kong Polytechnic University · HK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to explore behavioral changes of embryonic and larval zebrafish caused by pseudoephedrine hydrochloride (PSE) and its underlying mechanism. Zebrafish embryos were exposed to 0.5 µM, 2 µM, and 8 µM PSE at 4 h post-fertilization (4 hpf) or 22-23 hpf. Mortality, hatching rate, coiling frequency, heart rate, behavior changes, and related gene expression were observed at different developmental stages. PSE below 8 µM did not affect zebrafish mortality, hatching rate, and heart rate compared with the control group. For embryos, PSE caused an increase at 16-32 hpf in zebrafish coiling frequency which could be rescued by serotonin antagonist WAY100635. Similarly, PSE caused an increase in the swimming distance of zebrafish larvae at 120 hpf. PSE also elevated the expression of serotonin (5-HT)-related genes 5-htr1ab and tph2 and dopamine-related gene dbh. Behavioral changes in zebrafish embryos and larvae caused by PSE may be closely associated with increased expression of 5-HT and dopamine-related genes. This may be reflected that the behavioral changes in zebrafish are a possible PSE monitoring indicator.

Indexed as

Embryo, NonmammalianZebrafishAnimalsDopamineLarvaPseudoephedrineSerotoninDopaminePseudoephedrineSerotoninBehavioral changesDopaminePseudoephedrine hydrochlorideSerotoninZebrafish embryos

Identifiers

PMID35907131
OpenAlexW4288684421

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.