Evidence map›Paper›PMID 35906717›Full record

ArticleJournal of labelled compounds & radiopharmaceuticals2022

Highly effective liquid and solid phase extraction methods to concentrate radioiodine isotopes for radioiodination chemistry.

Christopher Davis, Chun Li, Ruirui Nie, Norman Guzzardi, Barbara Dworakowska, Pragalath Sadasivam, John Maher, Eric O Aboagye, Zhi Lu, Ran Yan

Open access · hybridAbstract read
In one paragraph

Article in Journal of labelled compounds & radiopharmaceuticals, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Biomaterials for biomarker imaging and detection.Journal of advanced research · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Christopher DavisSchool of Biomedical Engineering and Imaging Sciences, St. Thomas' Hospital, King's College London, London, UK.ORCID 0000-0002-9936-6779
Chun LiDepartment of Nuclear Medicine, First Affiliated Hospital of Dalian Medical University, Dalian, China.
Ruirui NieDepartment of Nuclear Medicine, First Affiliated Hospital of Dalian Medical University, Dalian, China.
Norman GuzzardiSchool of Biomedical Engineering and Imaging Sciences, St. Thomas' Hospital, King's College London, London, UK.
Barbara DworakowskaSchool of Biomedical Engineering and Imaging Sciences, St. Thomas' Hospital, King's College London, London, UK.ORCID 0000-0003-2706-2511
Pragalath SadasivamSchool of Biomedical Engineering and Imaging Sciences, St. Thomas' Hospital, King's College London, London, UK.
John MaherSchool of Cancer and Pharmaceutical Studies, Guy's Hospital, King's College London, London, UK.
Eric O AboagyeCancer Imaging Centre, Department of Surgery and Cancer, Imperial College, London, UK.
Zhi LuDepartment of Nuclear Medicine, First Affiliated Hospital of Dalian Medical University, Dalian, China.
Ran YanSchool of Biomedical Engineering and Imaging Sciences, St. Thomas' Hospital, King's College London, London, UK.ORCID 0000-0002-0303-3196
St Thomas' Hospital · GBDalian Medical University · CNCancer Imaging CentreGuy's Hospital · GB

Funding

UK Medical Research Council MR/N013700/1Wellcome WT 203148/Z/16/ZWellcome Trust
6 · The paper itself

Abstract

Radioactive iodine isotopes play a pivotal role in radiopharmaceuticals. Large-scale production of multi-patient dose of radioiodinated nuclear medicines requires high concentration of radioiodine. We demonstrate that tetrabutylammonium chloride and methyltrioctylamonium chloride are effective phase transfer reagents to concentrate iodide-124, iodide-125 and iodide-131 from the corresponding commercial water solutions. The resulting concentrated radioiodide, in the presence of either phase transfer reagent, does not hamper the chemical reactivity of aqueous radioiodide in the copper (II)-mediated one-pot three-component click chemistry to produce radioiodinated iodotriazoles.

Indexed as

Iodine RadioisotopesThyroid NeoplasmsChloridesCopperHumansIodidesRadiopharmaceuticalsSolid Phase ExtractionWaterChloridesCopperIodidesIodine RadioisotopesRadiopharmaceuticalsWateriodotriazolephase transfer reagentradioiodinationradioiodine

Identifiers

PMID35906717
PMCPMC9773003
OpenAlexW4288709711

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.