Evidence map›Paper›PMID 35906715›Full record

ArticleJournal of thrombosis and haemostasis : JTH2022

Good practice statements for antithrombotic therapy in the management of COVID-19: Guidance from the SSC of the ISTH.

Alex C Spyropoulos, Jean M Connors, James D Douketis, Mark Goldin, Beverley J Hunt, Taiwo R Kotila, Renato D Lopes, Sam Schulman, International Society on Thrombosis and Haemostasis

Open access · bronzeAbstract read
In one paragraph

Article in Journal of thrombosis and haemostasis : JTH, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
4.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.

  1. Pooled it
  2. Prophylactic anticoagulants for non-hospitalised people with COVID-19.The Cochrane database of systematic reviews · 2023
    Pooled it
  3. Trial
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Observational
  11. Article
  12. COVID-19 and cardiovascular disease in patients with chronic kidney disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024
    Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 8 institutions in 5 countries.

Alex C SpyropoulosInstitute of Health Systems Science-Feinstein Institutes for Medical Research, Manhasset, New York, USA.ORCID 0000-0002-3175-461X
Jean M ConnorsHematology Division Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0001-6445-582X
James D DouketisDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0001-5288-0394
Mark GoldinInstitute of Health Systems Science-Feinstein Institutes for Medical Research, Manhasset, New York, USA.ORCID 0000-0002-1147-5541
Beverley J HuntThrombosis & Haemophilia Centre, Guy's & St Thomas' NHS Foundation Trust, London, UK.ORCID 0000-0002-4709-0774
Taiwo R KotilaDepartment of Haematology, College of Medicine, University of Ibadan, Ibadan, Nigeria.ORCID 0000-0001-7355-7166
Renato D LopesDuke University Medical Center, Duke Clinical Research Institute, Department of Medicine, Division of Cardiology, Durham, North Carolina, USA.ORCID 0000-0003-2999-4961
Sam SchulmanDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0002-8512-9043
International Society on Thrombosis and Haemostasis
Brigham and Women's Hospital · USClinical Research Institute · USFeinstein Institute for Medical Research · USGuy's and St Thomas' NHS Foundation Trust · GBMcMaster University · CANorthwell Health · USSechenov University · RUUniversity of Ibadan · NG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite the emergence of high quality randomized trial data with the use of antithrombotic agents to reduce the risk of thromboembolism, end-organ failure, and possibly mortality in patients with coronavirus disease 2019 (COVID-19), questions still remain as to optimal patient selection for these strategies, the use of antithrombotics in outpatient settings and in-hospital settings (including critical care units), thromboprophylaxis in special patient populations, and the management of acute thrombosis in hospitalized COVID-19 patients. In October 2021, the International Society on Thrombosis and Haemostasis (ISTH) formed a multidisciplinary and international panel of content experts, two patient representatives, and a methodologist to develop recommendations on treatment with anticoagulants and antiplatelet agents for COVID-19 patients. The ISTH Guideline panel discussed additional topics to be well suited to a non-Grading of Recommendations Assessment, Development, and Evaluation (GRADE) for Good Practice Statements (GPS) to support good clinical care in the antithrombotic management of COVID-19 patients in various clinical settings. The GPS panel agreed on 17 GPS: 3 in the outpatient (pre-hospital) setting, 12 in the hospital setting both in non-critical care (ward) as well as intensive care unit settings, and 2 in the immediate post-hospital discharge setting based on limited evidence or expert opinion that supports net clinical benefit in enacting the statements provided. The antithrombotic therapies discussed in these GPS should be available in low- and middle-income countries.

Indexed as

COVID-19 Drug TreatmentFibrinolytic AgentsAnticoagulantsHemostasisHumansPlatelet Aggregation InhibitorsThrombosisVenous ThromboembolismAnticoagulantsFibrinolytic AgentsPlatelet Aggregation Inhibitorsanticoagulantantiplateletantithrombotic therapycoronavirus disease 2019hospitalizationsevere acute respiratory syndrome coronavirus 2

Identifiers

PMID35906715
PMCPMC9349985
OpenAlexW4284709425

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.