ArticleBMC cardiovascular disorders2022
Surgical treatment of patients with infective endocarditis: changes in temporal use, patient characteristics, and mortality-a nationwide study.
Article in BMC cardiovascular disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Conservative Versus Surgical Therapy in Patients With Infective Endocarditis and Surgical Indication-Meta-Analysis of Reconstructed Time-to-Event Data.Journal of the American Heart Association · 2024Pooled it
- Infective Endocarditis in Ireland: A Nationwide Analysis.Journal of clinical medicine · 2026Article
- Infective endocarditis in a university hospital without on-site cardiac surgery: temporal trends over 37 years.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- Infective Endocarditis: A Contemporary Review of Epidemiology, Diagnosis, and Management.Antibiotics (Basel, Switzerland) · 2026Review
- Management and outcomes of infective endocarditis in a community hospital and its cardiac surgery referral centre.Scientific reports · 2026Article
- Current Management of Infective Endocarditis: A Narrative Review Focused on Unmet Clinical Needs and the Multidisciplinary Approach.Journal of cardiovascular development and disease · 2026Review
- Association of Renal Impairment Severity with Surgical Outcomes in Patients with Infective Endocarditis.Current cardiology reviews · 2026Article
- Post-operative infection treatment in cardiac surgery: current practices and future directions.Perioperative medicine (London, England) · 2025Review
- Long-term mortality in patients who survive surgery for infective endocarditis versus the background population: a nationwide study.Open heart · 2025Article
- Infective endocarditis: it takes a team.European heart journal · 2025Review
- Clinical features and outcomes of infective endocarditis in persons experiencing homelessness.Infectious diseases of poverty · 2025Article
- Implications of pacemaker implantation after aortic valve surgery for endocarditis: a nationwide study†.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2025Observational
- Trends in the Clinical Characteristics and Outcome of Infective Endocarditis: A Nationwide Study From 2016 to 2021.Journal of the American Heart Association · 2025Article
- Surgery in patients with infective endocarditis and prognostic importance of patient frailty.Infection · 2024Article
- Role of echocardiography in the diagnosis and clinical management of infective endocarditis.Indian journal of thoracic and cardiovascular surgery · 2024Review
- Clinical Features and Patient Outcomes in Infective Endocarditis with Surgical Indication: A Single-Centre Experience.Journal of cardiovascular development and disease · 2024Article
- The Surgical Treatment of Infective Endocarditis: A Comprehensive Review.Diagnostics (Basel, Switzerland) · 2024Review
- Microbiological Etiology in Patients with IE Undergoing Surgery and for Patients with Medical Treatment Only: A Nationwide Study from 2010 to 2020.Microorganisms · 2023Article
- Infective endocarditis in developing countries: An update.Frontiers in cardiovascular medicine · 2022Review
Corrections and comments
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Authors and funding
18 authors at 8 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundValve surgery guidelines for infective endocarditis (IE) are unchanged over decades and nationwide data about the use of valve surgery do not exist.
methodsWe included patients with first-time IE (1999-2018) using Danish nationwide registries. Proportions of valve surgery were reported for calendar periods (1999-2003, 2004-2008, 2009-2013, 2014-2018). Comparing calendar periods in multivariable analyses, we computed likelihoods of valve surgery with logistic regression and rates of 30 day postoperative mortality with Cox regression.
resultsWe included 8804 patients with first-time IE; 1981 (22.5%) underwent surgery during admission, decreasing by calendar periods (N = 360 [24.4%], N = 483 [24.0%], N = 553 [23.5%], N = 585 [19.7%], P = < 0.001 for trend). For patients undergoing valve surgery, median age increased from 59.7 to 66.9 years (P ≤ 0.001) and the proportion of males increased from 67.8% to 72.6% (P = 0.008) from 1999-2003 to 2014-2018. Compared with 1999-2003, associated likelihoods of valve surgery were: Odds ratio (OR) = 1.14 (95% CI: 0.96-1.35), OR = 1.20 (95% CI: 1.02-1.42), and OR = 1.10 (95% CI: 0.93-1.29) in 2004-2008, 2009-2013, and 2014-2018, respectively. 30 day postoperative mortalities were: 12.7%, 12.8%, 6.9%, and 9.7% by calendar periods. Compared with 1999-2003, associated mortality rates were: Hazard ratio (HR) = 0.96 (95% CI: 0.65-1.41), HR = 0.43 (95% CI: 0.28-0.67), and HR = 0.55 (95% CI 0.37-0.83) in 2004-2008, 2009-2013, and 2014-2018, respectively.
conclusionsOn a nationwide scale, 22.5% of patients with IE underwent valve surgery. Patient characteristics changed considerably and use of valve surgery decreased over time. The adjusted likelihood of valve surgery was similar between calendar periods with a trend towards an increase while rates of 30 day postoperative mortality decreased.
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