ArticleScientific reports2022
Metabolic syndrome in patients with first-ever ischemic stroke: prevalence and association with coronary heart disease.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 22 citations in OpenAlex.
- Dual Antiplatelet Therapy in Patients With Metabolic Syndrome After Mild Ischemic Stroke or Transient Ischemic Attack.Journal of the American Heart Association · 2025Trial
- Heart-derived factors and organ cross-talk in settings of health and disease: new knowledge and clinical opportunities for multimorbidity.The Journal of physiology · 2026Review
- Comparison of Ischemic Stroke Outcomes in Patients With and Without Metabolic Syndrome: A Systematic Review.Cureus · 2025Review
- Association between TyG index with obesity indicators and coronary heart disease: a cohort study.Scientific reports · 2025Article
- Metabolic syndrome with mortality and major adverse cardiovascular events in an elderly population.Frontiers in endocrinology · 2025Article
- Metabolic Syndrome in Non-diabetic Stroke Patients.Cureus · 2024Article
- Association Between Overweight/Obesity Metabolic Phenotypes Defined by Two Criteria of Metabolic Abnormality and Cardiovascular Diseases: A Cross-Sectional Analysis in a Chinese Population.Clinical cardiology · 2024Article
- Integrated single cell-RNA sequencing and Mendelian randomization for ischemic stroke and metabolic syndrome.iScience · 2024Article
- Lipid-Derived Biomarkers as Therapeutic Targets for Chronic Coronary Syndrome and Ischemic Stroke: An Updated Narrative Review.Medicina (Kaunas, Lithuania) · 2024Review
- Optimal cut-off values of visceral fat area for predicting metabolic syndrome among patients with ischemic stroke: a cross-sectional study.Frontiers in neurology · 2024Article
- Early warning model for stroke recurrence in acute ischemic stroke patients based on traditional Chinese medicine syndrome theory.American journal of translational research · 2024Article
- Elevated Chinese visceral adiposity index increases the risk of stroke in Chinese patients with metabolic syndrome.Frontiers in endocrinology · 2023Article
- Elevated visceral adiposity index is associated with increased stroke prevalence and earlier age at first stroke onset: Based on a national cross-sectional study.Frontiers in endocrinology · 2022Article
- Metabolic syndrome and its associated factors among adults with cardiac diseases: A cross-sectional comparative group study.JRSM cardiovascular diseaseArticle
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Authors and funding
12 authors at 8 institutions in 3 countries.
Funding
Abstract
The metabolic syndrome (MetS) has been well linked with coronary heart disease (CHD) in the general population, but studies have rarely explored their association among patients with stroke. We examine prevalence of MetS and its association with CHD in patients with first-ever ischemic stroke. This hospital-based study included 1851 patients with first-ever ischemic stroke (mean age 61.2 years, 36.5% women) who were hospitalized into two university hospitals in Shandong, China (January 2016-February 2017). Data were collected through interviews, physical examinations, and laboratory tests. MetS was defined following the National Cholesterol Education Program (NCEP) criteria, the International Diabetes Federation (IDF) criteria, and the Chinese Diabetes Society (CDS) criteria. CHD was defined following clinical criteria. Data were analyzed using binary logistic regression models. The overall prevalence of MetS was 33.4% by NECP criteria, 47.2% by IDF criteria, and 32.5% by CDS criteria, with the prevalence being decreased with age and higher in women than in men (p < 0.05). High blood pressure, high triglycerides, and low HDL-C were significantly associated with CHD (multi-adjusted odds ratio [OR] range 1.27-1.38, p < 0.05). The multi-adjusted OR of CHD associated with MetS defined by the NECP criteria, IDF criteria, and CDS criteria (vs. no MetS) was 1.27 (95% confidence interval 1.03-1.57), 1.44 (1.18-1.76), and 1.27 (1.03-1.57), respectively. In addition, having 1-2 abnormal components (vs. none) of MetS was associated with CHD (multi-adjusted OR range 1.66-1.72, p < 0.05). MetS affects over one-third of patients with first-ever ischemic stroke. MetS is associated with an increased likelihood of CHD in stroke patients.
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