Evidence map›Paper›PMID 35906379›Full record

ArticleScientific reports2022

[

Hanwen Zhang, Diane Abou, Peng Lu, Abbie Meghan Hasson, Alexandria Villmer, Nadia Benabdallah, Wen Jiang, David Ulmert, Sean Carlin, Buck E Rogers and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. [Journal of clinical medicine · 2024
    Review
  3. Circulating Tumor DNA Biomarkers for Response Assessment in Prostate Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2023
    Article
  4. Targeted Alpha-Particle Therapy: A Review of Current Trials.International journal of molecular sciences · 2023
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 1 country.

Hanwen ZhangDepartment of Radiology, Washington University School of Medicine, 510 S. Kingshighway Blvd., Campus, Box 8225, St. Louis, MO, 63110, USA.
Diane AbouDepartment of Radiology, Washington University School of Medicine, 510 S. Kingshighway Blvd., Campus, Box 8225, St. Louis, MO, 63110, USA.
Peng LuDepartment of Radiology, Washington University School of Medicine, 510 S. Kingshighway Blvd., Campus, Box 8225, St. Louis, MO, 63110, USA.
Abbie Meghan HassonDepartment of Radiology, Washington University School of Medicine, 510 S. Kingshighway Blvd., Campus, Box 8225, St. Louis, MO, 63110, USA.
Alexandria VillmerDepartment of Radiology, Washington University School of Medicine, 510 S. Kingshighway Blvd., Campus, Box 8225, St. Louis, MO, 63110, USA.
Nadia BenabdallahDepartment of Radiology, Washington University School of Medicine, 510 S. Kingshighway Blvd., Campus, Box 8225, St. Louis, MO, 63110, USA.
Wen JiangProgram in Quantitative Molecular Therapeutics, Washington University School of Medicine, St. Louis, MO, USA.
David UlmertJohnsson Comprehensive Cancer Center, University of California, Los Angeles, CA, USA.
Sean CarlinDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
Buck E RogersProgram in Quantitative Molecular Therapeutics, Washington University School of Medicine, St. Louis, MO, USA.
Norman F TurtleDepartment of Radiology, Washington University School of Medicine, 510 S. Kingshighway Blvd., Campus, Box 8225, St. Louis, MO, 63110, USA.
Michael R McDevittDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Brian BaumannProgram in Quantitative Molecular Therapeutics, Washington University School of Medicine, St. Louis, MO, USA.
Brian W SimonsCenter for Comparative Medicine, Baylor College of Medicine, Houston, TX, USA.
Farrokh DehdashtiDepartment of Radiology, Washington University School of Medicine, 510 S. Kingshighway Blvd., Campus, Box 8225, St. Louis, MO, 63110, USA.
Dong ZhouDepartment of Radiology, Washington University School of Medicine, 510 S. Kingshighway Blvd., Campus, Box 8225, St. Louis, MO, 63110, USA. zhoud@wustl.edu.
Daniel L J ThorekDepartment of Radiology, Washington University School of Medicine, 510 S. Kingshighway Blvd., Campus, Box 8225, St. Louis, MO, 63110, USA. thorek.lab@wustl.edu.
Quantitative BioSciences · USWashington University in St. Louis · USBaylor College of Medicine · USJohns Hopkins University · USMemorial Sloan Kettering Cancer Center · USUniversity of California, Los Angeles · USUniversity of Pennsylvania · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI AIMEE S JAMES · 2001 to 2026
$128.0M
Imaging and Targeted Auger Radiotherapy of High-Grade GliomaR01EB029752 · NIBIB · WASHINGTON UNIVERSITY · PI GARBOW, JOEL RICHARD, ROGERS, BUCK E. · 2020 to 2023
$3.1M
Opening the Therapeutic Window for PSMA-Targeted Molecular RadiotherapyR01CA229893 · NCI · WASHINGTON UNIVERSITY · PI THOREK, DANIEL LYNDON JAFFE · 2019 to 2024
$1.9M
Kallikrein-Targeted Alpha-Particle Therapy of Late-Stage Prostate CancerR01CA201035 · NCI · WASHINGTON UNIVERSITY · PI THOREK, DANIEL LYNDON JAFFE · 2017 to 2020
$1.4M
NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA091842NCI NIH HHS R01 CA201035NCI NIH HHS R01 CA229893NIBIB NIH HHS R01 EB029752
6 · The paper itself

Abstract

The growing interest and clinical translation of alpha particle (α) therapies brings with it new challenges to assess target cell engagement and to monitor therapeutic effect. Noninvasive imaging has great potential to guide α-treatment and to harness the potential of these agents in the complex environment of disseminated disease. Poly(ADP) ribose polymerase 1 (PARP-1) is among the most abundantly expressed DNA repair enzymes with key roles in multiple repair pathways-such as those induced by irradiation. Here, we used a third-generation PARP1-specific radiotracer, [

Indexed as

Fluorine RadioisotopesProstatic NeoplasmsAlpha ParticlesHumansKineticsMalePoly(ADP-ribose) Polymerase InhibitorsPositron-Emission TomographyTomography, X-Ray ComputedFluorine RadioisotopesPoly(ADP-ribose) Polymerase Inhibitors

Identifiers

PMID35906379
PMCPMC9338249
OpenAlexW4288535576

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.