Evidence map›Paper›PMID 35906283›Full record

SynthesisJournal of perinatology : official journal of the California Perinatal Association2023

Impact of prenatal opioids on cardiac and autonomic development: systematic review and meta-analysis.

Meghan P Howell, Carlie A Wiseman, Maya Z Rosen, Winifred M Yeates, Laura A Wright, Samantha S O'Connell, Benjamin Bhunu, Suttira Intapad, Thomas R Kimball, Stefanie Cheang and 1 more

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Journal of perinatology : official journal of the California Perinatal Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Meghan P HowellDepartment of Pediatrics, Tulane University School of Medicine, New Orleans, LA, USA. mhowell2@tulane.edu.ORCID http://orcid.org/0000-0002-7940-8644
Carlie A WisemanSchool of Science and Engineering, Tulane University, New Orleans, LA, USA.
Maya Z RosenSchool of Public Health, Tulane University, New Orleans, LA, USA.ORCID http://orcid.org/0000-0002-5923-4747
Winifred M YeatesSchool of Medicine, Tulane University, New Orleans, LA, USA.
Laura A WrightRudolph Matas Library of Health Sciences, Tulane University, New Orleans, LA, USA.
Samantha S O'ConnellOffice of Academic Affairs and Provost, Tulane University School of Medicine, New Orleans, LA, USA.
Benjamin BhunuDepartment of Pharmacology, Tulane University School of Medicine, New Orleans, LA, USA.
Suttira IntapadDepartment of Pharmacology, Tulane University School of Medicine, New Orleans, LA, USA.
Thomas R KimballDepartment of Pediatrics, Section of Pediatric Cardiology, Louisiana State University School of Medicine, New Orleans, LA, USA.
Stefanie CheangDepartment of Pediatrics, Section of Pediatric Cardiology, Louisiana State University School of Medicine, New Orleans, LA, USA.
Kelly K GajewskiDepartment of Pediatrics, Section of Pediatric Cardiology, Louisiana State University School of Medicine, New Orleans, LA, USA.
Tulane University · USLouisiana State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prenatal opioid exposure has recently risen four-fold with limited data on the developmental effects on neonatal physiology. The objective of this systematic review is to develop an association between prenatal opioid exposure and fetal and neonatal cardiac and autonomic development and function. The review was conducted in accordance with PRISMA Guidelines, and searches were conducted using PubMed, Embase, CINAHL, and Web of Science between May 25 and October 27, 2020. Twenty studies fit inclusion criteria, in four categories: (1) fetal cardiac outcomes, (2) neonatal cardiac outcomes, (3) noninvasive autonomic outcomes, and (4) clinical and behavioral measures. For the meta-analysis, three studies (total of 210 subjects) were included. Effect sizes were measured as the mean difference in fetal heart rate between opioid-exposed and non-exposed groups. Mothers with prenatal opioid use had a significantly lower fetal heart rate as compared to mothers without prenatal opioid use, requiring further studies to determine clinical significance.

Indexed as

Analgesics, OpioidOpioid-Related DisordersFemaleFetusHumansInfant, NewbornMothersPregnancyPrenatal CareAnalgesics, Opioid

Identifiers

PMID35906283
OpenAlexW4288705200

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.