ArticleNature communications2022
Orbitofrontal cortex contributes to the comparison of values underlying economic choices.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 34 citations in OpenAlex.
- Article
- Subjective Values in Decision-Making Under Uncertainty: A Systematic Review.Behavioral sciences (Basel, Switzerland) · 2026Review
- Closed-loop readout of anterior insula high-gamma activity steers value-based decisions.Nature communications · 2026Article
- Orbitofrontal-sensory cortical interactions in learning and adaptive decision-making.Trends in cognitive sciences · 2026Review
- Neuronal Activity in Orbitofrontal Cortex during Trinary Choices under Risk.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Article
- A neural circuit framework for economic choice: from building blocks of valuation to compositionality in multitasking.bioRxiv : the preprint server for biology · 2025Article
- Neuronal Activity in Orbitofrontal Cortex during Trinary Choices under Risk.bioRxiv : the preprint server for biology · 2025Article
- Orbitofrontal cortex computes gaze-dependent comparisons between attributes rather than integrated values.PLoS biology · 2025Article
- Orbitofrontal High-Gamma Reflects Spike-Dissociable Value and Decision Mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- The representation of decision variables in orbitofrontal cortex is longitudinally stable.Cell reports · 2024Article
- Review
- Direct stimulation of anterior insula and ventromedial prefrontal cortex disrupts economic choices.Nature communications · 2024Article
- Neuronal Activity in the Gustatory Cortex during Economic Choice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Article
- Gaze-centered gating, reactivation, and reevaluation of economic value in orbitofrontal cortex.Nature communications · 2024Article
- Article
- A neural mechanism for conserved value computations integrating information and rewards.Nature neuroscience · 2024Article
- The orbitofrontal cortex: A goal-directed cognitive map framework for social and non-social behaviors.Neurobiology of learning and memory · 2023Review
- Distinct roles of the orbitofrontal cortex, ventral striatum, and dopamine neurons in counterfactual thinking of decision outcomes.Science advances · 2023Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
Economic choices between goods entail the computation and comparison of subjective values. Previous studies examined neuronal activity in the orbitofrontal cortex (OFC) of monkeys choosing between different types of juices. Three groups of neurons were identified: offer value cells encoding the value of individual offers, chosen juice cells encoding the identity of the chosen juice, and chosen value cells encoding the value of the chosen offer. The encoded variables capture both the input (offer value) and the output (chosen juice, chosen value) of the decision process, suggesting that values are compared within OFC. Recent work demonstrates that choices are causally linked to the activity of offer value cells. Conversely, the hypothesis that OFC contributes to value comparison has not been confirmed. Here we show that weak electrical stimulation of OFC specifically disrupts value comparison without altering offer values. This result implies that neuronal populations in OFC participate in value comparison.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.