Evidence map›Paper›PMID 35906236›Full record

ArticleNature communications2022

Mouse fetal growth restriction through parental and fetal immune gene variation and intercellular communications cascade.

Gurman Kaur, Caroline B M Porter, Orr Ashenberg, Jack Lee, Samantha J Riesenfeld, Matan Hofree, Maria Aggelakopoulou, Ayshwarya Subramanian, Subita Balaram Kuttikkatte, Kathrine E Attfield and 15 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Effects of the gut microbiota on placental angiogenesis and intrauterine growth in gnotobiotic mice.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Innate Lymphoid Cells in Reproductive Health and Disease.European journal of immunology · 2025
    Review
  6. Review
  7. Article
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 7 institutions in 4 countries.

Gurman Kaur *MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.ORCID 0000-0001-7722-3956
Caroline B M Porter *Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Orr AshenbergKlarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Jack LeeDepartment of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.
Samantha J RiesenfeldKlarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0001-9144-021X
Matan HofreeKlarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0001-8368-0299
Maria AggelakopoulouOxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Ayshwarya SubramanianKlarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-4134-7612
Subita Balaram KuttikkatteMRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Kathrine E AttfieldOxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.ORCID 0000-0003-3387-521X
Christiane A E DeselOxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.ORCID 0000-0003-2029-3851
Jessica L DaviesOxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.ORCID 0000-0002-8888-1441
Hayley G EvansOxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Inbal Avraham-DavidiKlarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0001-7118-9179
Lan T NguyenKlarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Danielle A DionneKlarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Anna E NeumannBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0001-7115-8305
Lise Torp JensenDepartment of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark.
Thomas R BarberMRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Elizabeth SoilleuxDepartment of Pathology, Tennis Court Rd, University of Cambridge, Cambridge, England.ORCID 0000-0002-4032-7249
Mary CarringtonBasic Science Program, Frederick National Laboratory for Cancer Research in the Laboratory of Integrative Cancer Immunology, National Cancer Institute, Bethesda, MD, USA.ORCID 0000-0002-2692-2180
Gil McVeanBig Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.ORCID 0000-0002-5012-4162
Orit Rozenblatt-RosenKlarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0001-6313-3570
Aviv RegevKlarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA. aregev@broadinstitute.org.
Lars FuggerMRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK. lars.fugger@ndcn.ox.ac.uk.ORCID 0000-0003-2883-3226
Broad Institute · USJohn Radcliffe Hospital · GBAarhus University Hospital · DKKing's College London · GBRagon Institute of MGH, MIT and Harvard · USUniversity of Cambridge · GBUniversity of Oxford · GB

Funding

Investigating Human Adipocyte HeterogeneityRC2DK116691 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Orr Ashenberg, Noel P Burtt · 2018 to 2026
$17.8M
CCR NIH HHS HHSN261200800001CDepartment of HealthHoward Hughes Medical InstituteMedical Research Council G0902418Medical Research Council MC_UU_00008/3Medical Research Council MC_UU_12009Medical Research Council MC_UU_12010/3Medical Research Council MC_UU_12025NCI NIH HHS HHSN261200800001ENIDDK NIH HHS RC2 DK116691NIH HHS HHSN261200800001EWellcome TrustWellcome Trust 100308/Z/12/ZWellcome Trust 100956/Z/13/Z
6 · The paper itself

Abstract

Fetal growth restriction (FGR) affects 5-10% of pregnancies, and can have serious consequences for both mother and child. Prevention and treatment are limited because FGR pathogenesis is poorly understood. Genetic studies implicate KIR and HLA genes in FGR, however, linkage disequilibrium, genetic influence from both parents, and challenges with investigating human pregnancies make the risk alleles and their functional effects difficult to map. Here, we demonstrate that the interaction between the maternal KIR2DL1, expressed on uterine natural killer (NK) cells, and the paternally inherited HLA-C*0501, expressed on fetal trophoblast cells, leads to FGR in a humanized mouse model. We show that the KIR2DL1 and C*0501 interaction leads to pathogenic uterine arterial remodeling and modulation of uterine NK cell function. This initial effect cascades to altered transcriptional expression and intercellular communication at the maternal-fetal interface. These findings provide mechanistic insight into specific FGR risk alleles, and provide avenues of prevention and treatment.

Indexed as

Fetal Growth RetardationTrophoblastsAnimalsCell CommunicationFemaleFetusHLA-C AntigensMicePregnancyHLA-C Antigens

Identifiers

PMID35906236
PMCPMC9338297
OpenAlexW4288704581

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.