Evidence map›Paper›PMID 35906190›Full record

ArticleThe American journal of clinical nutrition2022

A healthy plant-based diet was associated with slower cognitive decline in African American older adults: a biracial community-based cohort.

Xiaoran Liu, Klodian Dhana, Lisa L Barnes, Christy C Tangney, Puja Agarwal, Neelum Aggarwal, Thomas M Holland, Todd Beck, Denis A Evans, Kumar B Rajan

Open access · greenAbstract read
In one paragraph

Article in The American journal of clinical nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 2 pooled it
5.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.

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  20. Diets to promote healthy brain ageing.Nature reviews. Neurology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Xiaoran LiuRush Institute for Healthy Aging, Rush University Medical Center, Chicago, IL, USA.ORCID 0000-0001-7356-645X
Klodian DhanaRush Institute for Healthy Aging, Rush University Medical Center, Chicago, IL, USA.ORCID 0000-0002-6397-7009
Lisa L BarnesRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Christy C TangneyDepartment of Clinical Nutrition & Preventive Medicine, Rush University Medical Center, Chicago, IL, USA.
Puja AgarwalDepartment of Internal Medicine, Rush University Medical Center, Chicago, IL, USA.
Neelum AggarwalRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Thomas M HollandRush Institute for Healthy Aging, Rush University Medical Center, Chicago, IL, USA.
Todd BeckRush Institute for Healthy Aging, Rush University Medical Center, Chicago, IL, USA.
Denis A EvansRush Institute for Healthy Aging, Rush University Medical Center, Chicago, IL, USA.
Kumar B RajanRush Institute for Healthy Aging, Rush University Medical Center, Chicago, IL, USA.
Rush University Medical Center · US

Funding

Impact of Neuroinflammation on AD Occurrence: A Bi-Generational Population StudyR01AG073627 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI NEELUM T. AGGARWAL, DENIS A EVANS · 2021 to 2026
$14.0M
Preserving Cognitive Resilience: A Biracial Parent-Offspring Study (18-4674) - Feasibility StudyR01AG058679 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI EVANS, DENIS A, RAJAN, KUMAR B. · 2019 to 2024
$13.8M
Factors Influencing Decline in AD Trends in a Biracial Population StudyRF1AG057532 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI RAJAN, KUMAR B. · 2017 to 2017
$1.7M
Nonlinear Models of Cognition Preceding AD in a Biracial Population SampleR01AG051635 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI RAJAN, KUMAR B. · 2016 to 2020
$1.5M
NIA NIH HHS R01AG03154NIA NIH HHS R01 AG051635NIA NIH HHS R01 AG058679NIA NIH HHS R01 AG073627NIH HHS RF1AG057532
6 · The paper itself

Abstract

backgroundAfrican American (AA) adults have about twice the risk of developing dementia compared with white adults. However, evidence on dietary modification in preventing cognitive decline from diverse populations focusing on AA adults is minimal.

objectivesWe aimed to evaluate the association between a plant-based diet and the rate of cognitive decline in a population-based sample of AA and white adults.

methodsThis study consisted of 3337 participants from the Chicago Health and Aging Project (60% AA participants, 64% female). Plant-based diet quality was evaluated by the overall plant-based diet index (PDI), the healthful PDI (hPDI), and the unhealthful PDI (uPDI). Global cognition was assessed using a composite score of 4 individual tests of cognition. We used mixed models to examine the associations of PDI, hPDI, and uPDI with the rates of decline in global cognition, perceptual speed, and episodic memory. Models were adjusted for age, sex, presence of apoE e4 allele, lifestyle factors including education, cognitive activities, smoking status, calorie intake, risk factors for cardiovascular disease, time, and the interaction terms of time × each covariate.

resultsAA and white participants had various dietary patterns. Higher hPDI was associated with a slower rate of decline in global cognition, perceptual speed, and episodic memory in AA participants but not white participants. AA study participants in the highest quintile of hPDI had significantly slower rates of global cognitive decline (β: 0.0183 ± 0.0086; P = 0.032), perceptual speed (β: 0.0179 ± 0.0088; P = 0.04), and episodic memory (β: 0.0163 ± 0.0118; P = 0.04) than individuals in the lowest quintile of hPDI. There were no associations of either PDI or uPDI with the rate of cognitive decline in either racial group.

conclusionsA healthy plant-based diet was associated with a slower rate of decline in global cognition, perceptual speed, and episodic memory in AA adults.

Indexed as

Black or African AmericanCognitive DysfunctionAgedApolipoproteins ECohort StudiesDietDiet, VegetarianHumansApolipoproteins EAfrican Americansbiracialcognitioncognitive declinedietdietary patternepisodic memorylongitudinal cohortperceptual speedplant-based diet

Identifiers

PMID35906190
PMCPMC9535523
OpenAlexW4288712688

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.