Evidence map›Paper›PMID 35905722›Full record

ArticleCell reports2022

Activation, but not inhibition, of the indirect pathway disrupts choice rejection in a freely moving, multiple-choice foraging task.

Kristen Delevich, Benjamin Hoshal, Lexi Z Zhou, Yuting Zhang, Satya Vedula, Wan Chen Lin, Juliana Chase, Anne G E Collins, Linda Wilbrecht

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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  7. Dopamine and Norepinephrine Differentially Mediate the Exploration-Exploitation Tradeoff.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kristen DelevichDepartment of Psychology, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Integrative Physiology and Neuroscience, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA.
Benjamin HoshalDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Lexi Z ZhouDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Yuting ZhangDepartment of Psychology, University of California, Berkeley, Berkeley, CA 94720, USA.
Satya VedulaDepartment of Psychology, University of California, Berkeley, Berkeley, CA 94720, USA.
Wan Chen LinDepartment of Psychology, University of California, Berkeley, Berkeley, CA 94720, USA; Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
Juliana ChaseDepartment of Psychology, University of California, Berkeley, Berkeley, CA 94720, USA.
Anne G E CollinsDepartment of Psychology, University of California, Berkeley, Berkeley, CA 94720, USA; Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
Linda WilbrechtDepartment of Psychology, University of California, Berkeley, Berkeley, CA 94720, USA; Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: wilbrecht@berkeley.edu.

Funding

Towards a Unified Framework for Dopamine Signaling in the StriatumU19NS113201 · NINDS · HARVARD MEDICAL SCHOOL · PI UCHIDA, NAOSHIGE · 2019 to 2023
$18.7M
Corticostriatal circuits in behavioral flexibilityF32MH110184 · NIMH · UNIVERSITY OF CALIFORNIA BERKELEY · PI DELEVICH, KRISTEN MARIE · 2016 to 2018
$171k
NIMH NIH HHS F32 MH110184NINDS NIH HHS U19 NS113201
6 · The paper itself

Abstract

The dorsomedial striatum (DMS) plays a key role in action selection, but less is known about how direct and indirect pathway spiny projection neurons (dSPNs and iSPNs, respectively) contribute to choice rejection in freely moving animals. Here, we use pathway-specific chemogenetic manipulation during a serial choice foraging task to test the role of dSPNs and iSPNs in learned choice rejection. We find that chemogenetic activation, but not inhibition, of iSPNs disrupts rejection of nonrewarded choices, contrary to predictions of a simple "select/suppress" heuristic. Our findings suggest that iSPNs' role in stopping and freezing does not extend in a simple fashion to choice rejection in an ethological, freely moving context. These data may provide insights critical for the successful design of interventions for addiction or other conditions in which it is desirable to strengthen choice rejection.

Indexed as

Corpus StriatumNeuronsAnimalsLearningNeostriatumNeuriteschoice rejectionCP: Neurosciencedecision makingdirect pathwaydorsomedial striatumexplore-exploitindirect pathwayreinforcement learningstriatum

Identifiers

PMID35905722
PMCPMC10481643

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.