ArticleCell reports2022
Dynamic control of visually guided locomotion through corticosubthalamic projections.
Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
- Article
- Repeated alcohol drinking in mice is associated with bidirectional alterations in corticostriatal coherence.Neuropharmacology · 2025Article
- Inhibitory control of speech production in the human premotor frontal cortex.Nature human behaviour · 2025Article
- Dissociable roles of central striatum and anterior lateral motor area in initiating and sustaining naturalistic behavior.Cell reports · 2025Article
- Effects of chronic stress on cognitive function - From neurobiology to intervention.Neurobiology of stress · 2024Review
- Wide-field calcium imaging of cortical activation and functional connectivity in externally- and internally-driven locomotion.Nature communications · 2024Article
- Movement-related increases in subthalamic activity optimize locomotion.Cell reports · 2024Article
- Adaptation of sequential action benefits from timing variability related to lateral basal ganglia circuitry.iScience · 2024Article
- The Secondary Motor Cortex-striatum Circuit Contributes to Suppressing Inappropriate Responses in Perceptual Decision Behavior.Neuroscience bulletin · 2023Article
- Bio-Inspired Design of Superconducting Spiking Neuron and Synapse.Nanomaterials (Basel, Switzerland) · 2023Article
- Cell and circuit complexity of the external globus pallidus.Nature neuroscience · 2023Review
- Algebraic approach for subspace decomposition and clustering of neural activity.STAR protocols · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Goal-directed locomotion requires control signals that propagate from higher order areas to regulate spinal mechanisms. The corticosubthalamic hyperdirect pathway offers a short route for cortical information to reach locomotor centers in the brainstem. We developed a task in which head-fixed mice run to a visual landmark and then stop and wait to collect the reward and examined the role of secondary motor cortex (M2) projections to the subthalamic nucleus (STN) in controlling locomotion. Our behavioral modeling, calcium imaging, and optogenetics manipulation results suggest that the M2-STN pathway can be recruited during visually guided locomotion to rapidly and precisely control the pedunculopontine nucleus (PPN) of the mesencephalic locomotor region through the basal ganglia. By capturing the physiological dynamics through a feedback control model and analyzing neuronal signals in M2, PPN, and STN, we find that the corticosubthalamic projections potentially control PPN activity by differentiating an M2 error signal to ensure fast input-output dynamics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.