Evidence map›Paper›PMID 35905586›Full record

ArticleJournal of critical care2022

Association of early sedation level with patient outcomes in moderate-to-severe acute respiratory distress syndrome: Propensity-score matched analysis.

Jessica A Palakshappa, Gregory B Russell, Kevin W Gibbs, Chad Kloefkorn, Douglas Hayden, Marc Moss, Catherine L Hough, D Clark Files, NHLBI PETAL Network

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of critical care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Jessica A PalakshappaSection of Pulmonary, Critical Care, Allergy, and Immunologic Diseases, Wake Forest School of Medicine, Winston-Salem, NC, United States of America. Electronic address: jpalaksh@wakehealth.edu.
Gregory B RussellDepartment of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC, United States of America.
Kevin W GibbsSection of Pulmonary, Critical Care, Allergy, and Immunologic Diseases, Wake Forest School of Medicine, Winston-Salem, NC, United States of America.
Chad KloefkornDivision of Pulmonary, Allergy, and Critical Care Medicine, Duke University, Durham, NC, United States of America.
Douglas HaydenBiostatistics Center, Massachusetts General Hospital, United States of America.
Marc MossDivision of Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, Aurora, CO, United States of America.
Catherine L HoughDivision of Pulmonary, Allergy, and Critical Care Medicine, Oregon Health & Science University, Portland, OR, United States of America.
D Clark FilesSection of Pulmonary, Critical Care, Allergy, and Immunologic Diseases, Wake Forest School of Medicine, Winston-Salem, NC, United States of America.
NHLBI PETAL Network
Wake Forest University · USDuke University · USMassachusetts General Hospital · USOregon Health & Science University · USUniversity of Colorado Denver · US

Funding

CCC for NHLBI Prevention and Early Treatment of Acute Lung Injury PETAL NetworkU01HL123009 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI FOULKES, ANDREA S, THOMPSON, BOYD TAYLOR · 2014 to 2021
$67.2M
Clinical Centers (CC) for the NHLBI Prevention and Early Treatment of Acute LungU01HL123022 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SHAPIRO, NATHAN I, TALMOR, DANIEL STUART · 2014 to 2020
$2.9M
Prevention and Early Treatment of Acute Lung InjuryU01HL123004 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MATTHAY, MICHAEL A. · 2014 to 2020
$2.6M
Clinical Centers (CC) for the NHLBI Prevention and Early Treatment of Acute LungU01HL123031 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HYZY, ROBERT C, PARK, PAULINE K · 2014 to 2020
$2.6M
Enhancing the Surrogate Informed Consent Process for Critical Care ResearchU01HL123010 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI GINDE, ADIT A., MOSS, MARC · 2014 to 2020
$2.6M
Prevention and Early Treatment of Acute Lung Injury Clinical Trials NetworkU01HL123033 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICE, TODD W · 2014 to 2020
$2.4M
Preventive and Early Treatment of Acute Lung Injury Clinical Trials Network- Pgh - SupplementU01HL123020 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ANGUS, DEREK C, YEALY, DONALD M · 2014 to 2020
$2.4M
Long Term Outcomes and Macrophage Biology in Patients with EVALIU01HL123018 · NHLBI · IHC HEALTH SERVICES, INC. · PI BLEDSOE, JOSEPH R, BROWN, SAMUEL MORRIS · 2014 to 2020
$2.4M
Pacific Northwest Clinical Center for the NHLBI PETAL NetworkU01HL123008 · NHLBI · UNIVERSITY OF WASHINGTON · PI HOUGH, CATHERINE LEE, ROBINSON, BRYCE · 2014 to 2020
$2.3M
Acute Lung Injury Group New England Program to Support PETAL Network ResearchU01HL122989 · NHLBI · BAYSTATE MEDICAL CENTER, INC. · PI STEINGRUB, JAY S · 2014 to 2020
$2.2M
Einstein PETAL: Clinical Center for the PETAL NetworkU01HL122998 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI GONG, MICHELLE NG, RICHARDSON, LYNNE D. · 2014 to 2020
$1.9M
Wake Forest Clinical Center for the NHLBI PETAL NetworkU01HL123027 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI FILES, DANIEL CLARK, MILLER, CHADWICK DAVID · 2014 to 2020
$1.8M
NHLBI NIH HHS K24 HL141526NHLBI NIH HHS U01 HL122989NHLBI NIH HHS U01 HL122998NHLBI NIH HHS U01 HL123004NHLBI NIH HHS U01 HL123008NHLBI NIH HHS U01 HL123009NHLBI NIH HHS U01 HL123010NHLBI NIH HHS U01 HL123018NHLBI NIH HHS U01 HL123020NHLBI NIH HHS U01 HL123022NHLBI NIH HHS U01 HL123023NHLBI NIH HHS U01 HL123027NHLBI NIH HHS U01 HL123031NHLBI NIH HHS U01 HL123033NIA NIH HHS K23 AG073529NIGMS NIH HHS K08 GM123322
6 · The paper itself

Abstract

purposeStudies of early depth of sedation in mixed critically ill populations have suggested benefit to light sedation; however, the relationship of early depth of sedation with outcomes in patients with acute respiratory distress syndrome (ARDS) is unknown. MATERIALS AND

methodsWe performed a propensity-score matched analysis of early light sedation (Richmond Agitation Sedation Scale Score, RASS 0 to -1 or equivalent) versus deep sedation (RASS -2 or lower) in patients enrolled in the non-intervention group of The Reevaluation of Systemic Early Neuromuscular Blockade trial. Primary outcome was 90 day mortality. Secondary outcomes included days free of mechanical ventilation, days not in ICU, days not in hospital at day 28.

results137 of 486 participants (28.2%) received early light sedation. Vasopressor usage and Apache III scores significantly differed between groups. Prior to matching, 90-day mortality was higher in the early deep sedation (45.3%) compared to light sedation (34.2%) group. In the propensity score matched cohort, there was no difference in 90-day mortality (Odds Ratio (OR) 0.72, 95% CI 0.41, 1.27, p = 0.26) or secondary outcomes between the groups.

conclusionsWe did not find an association between early depth of sedation and clinical outcomes in this cohort of patients with moderate-to-severe ARDS.

Indexed as

Hypnotics and SedativesRespiratory Distress SyndromeHumansIntensive Care UnitsPropensity ScoreRespiration, ArtificialHypnotics and SedativesAcute respiratory distress syndromePropensity scoreSedation

Identifiers

PMID35905586
PMCPMC9419605
OpenAlexW4288032508

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.