Evidence map›Paper›PMID 35905313›Full record

ArticleGut microbes

Gut bacteria interact directly with colonic mast cells in a humanized mouse model of IBS.

Chiko Shimbori, Giada De Palma, Lauren Baerg, Jun Lu, Elena F Verdu, David E Reed, Stephen Vanner, Stephen M Collins, Premysl Bercik

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 31 citations in OpenAlex.

  1. Trial
  2. Gut microbes · 2026
    Article
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  6. Review
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  9. Article
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  12. Role of CD34 in inflammatory bowel disease.Frontiers in physiology · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Chiko ShimboriFarncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON, Canada.
Giada De PalmaFarncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON, Canada.
Lauren BaergFarncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON, Canada.
Jun LuFarncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON, Canada.
Elena F VerduFarncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON, Canada.
David E ReedGIDRU, Queen's University, Kingston, ON, Canada.
Stephen VannerGIDRU, Queen's University, Kingston, ON, Canada.
Stephen M CollinsFarncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON, Canada.
Premysl BercikFarncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON, Canada.ORCID 0000-0001-8707-1781
Population Health Research Institute · CAQueen's University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Both mast cells and microbiota play important roles in the pathogenesis of Irritable Bowel Syndrome (IBS), however the precise mechanisms are unknown. Using microbiota-humanized IBS mouse model, we show that colonic mast cells and mast cells co-localized with neurons were higher in mice colonized with IBS microbiota compared with those with healthy control (HC) microbiota.

Indexed as

Gastrointestinal MicrobiomeIrritable Bowel SyndromeAnimalsBacteriaDisease Models, AnimalIntestinal MucosaMast CellsMiceToll-Like Receptor 4Toll-Like Receptor 4bacteriahistamine 4 receptorIrritable bowel syndromemast cellsmicrobiotatoll-like receptor 4

Identifiers

PMID35905313
PMCPMC9341375
OpenAlexW4288697520

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.