ArticleScience advances2022
A biomineral-inspired approach of synthesizing colloidal persistent phosphors as a multicolor, intravital light source.
Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 38 citations in OpenAlex.
- Ambient Light-Activatable Luminescent Particle-Embedded Conformal Patch for Photochemical Tissue Bonding and Photobiomodulated Healing.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Molecular afterglow imaging for biomedical applications.Nature materials · 2025Review
- Controllable Doping for Tunable and Multimodal Emission in ZnS-Based Mechanoluminescent Nanocrystals.Nano letters · 2025Article
- Adaptive electronics for photovoltaic, photoluminescent and photometric methods in power harvesting for wireless wearable sensors.Nature communications · 2025Article
- Size and Structural Control of Mechanoluminescent ZnS:MnACS nano · 2025Article
- Force-Based Neuromodulation.Accounts of chemical research · 2024Review
- Modulating Smart Mechanoluminescent Phosphors for Multistimuli Responsive Optical Wood.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Ultrasound-Induced Cascade Amplification in a Mechanoluminescent Nanotransducer for Enhanced Sono-Optogenetic Deep Brain Stimulation.ACS nano · 2023Article
- Activation of mechanoluminescent nanotransducers by focused ultrasound enables light delivery to deep-seated tissue in vivo.Nature protocols · 2023Article
- Wireless deep-brain neuromodulation using photovoltaics in the second near-infrared spectrum.Device · 2023Article
- Principles and applications of sono-optogenetics.Advanced drug delivery reviews · 2023Review
- Ultrasound-activated luminescence with color tunability enabled by mechanoluminescent colloids and perovskite quantum dots.Nanoscale · 2023Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Many in vivo biological techniques, such as fluorescence imaging, photodynamic therapy, and optogenetics, require light delivery into biological tissues. The limited tissue penetration of visible light discourages the use of external light sources and calls for the development of light sources that can be delivered in vivo. A promising material for internal light delivery is persistent phosphors; however, there is a scarcity of materials with strong persistent luminescence of visible light in a stable colloid to facilitate systemic delivery in vivo. Here, we used a bioinspired demineralization (BID) strategy to synthesize stable colloidal solutions of solid-state phosphors in the range of 470 to 650 nm and diameters down to 20 nm. The exceptional brightness of BID-produced colloids enables their utility as multicolor luminescent tags in vivo with favorable biocompatibility. Because of their stable dispersion in water, BID-produced nanophosphors can be delivered systemically, acting as an intravascular colloidal light source to internally excite genetically encoded fluorescent reporters within the mouse brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.