ArticleScience advances2022
Itch-specific neurons in the ventrolateral orbital cortex selectively modulate the itch processing.
Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- The basolateral amygdala decodes visceral pain and itch via distinct circuits and molecules.Nature communications · 2026Article
- Ventrolateral orbital cortex as a functional hub in chronic pain and comorbid depression.Frontiers in neuroscience · 2026Article
- Article
- Harnessing the Tet-Off system for effective gene silencing inFrontiers in plant science · 2025Article
- Neural pathways that compel us to scratch an itch.Journal of biosciences · 2024Review
- The Anterior Insula and its Projection to the Prelimbic Cortex are Involved in the Regulation of 5-HT-Induced Itch.Neuroscience bulletin · 2023Article
- A common neuronal ensemble in nucleus accumbens regulates pain-like behaviour and sleep.Nature communications · 2023Article
- Loosely synchronized activation of anterior cingulate cortical neurons for scratching response during histamine-induced itch.Molecular brain · 2023Article
- Article
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Authors and funding
12 authors.
Funding
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Abstract
Itch is a cutaneous sensation that is critical in driving scratching behavior. The long-standing question of whether there are specific neurons for itch modulation inside the brain remains unanswered. Here, we report a subpopulation of itch-specific neurons in the ventrolateral orbital cortex (VLO) that is distinct from the pain-related neurons. Using a Tet-Off cellular labeling system, we showed that local inhibition or activation of these itch-specific neurons in the VLO significantly suppressed or enhanced itch-induced scratching, respectively, whereas the intervention did not significantly affect pain. Conversely, suppression or activation of pain-specific neurons in the VLO significantly affected pain but not itch. Moreover, fiber photometry and immunofluorescence verified that these itch- and pain-specific neurons are distinct in their functional activity and histological location. In addition, the downstream targets of itch- and pain-specific neurons were different. Together, the present study uncovers an important subpopulation of neurons in the VLO that specifically modulates itch processing.
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Registered trials
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