Evidence map›Paper›PMID 35905080›Full record

ArticlePloS one2022

Prospective audit and feedback implementation by a multidisciplinary antimicrobial stewardship team shortens the time to de-escalation of anti-MRSA agents.

Ryo Yamaguchi, Takehito Yamamoto, Koh Okamoto, Keita Tatsuno, Mahoko Ikeda, Takehiro Tanaka, Yoshitaka Wakabayashi, Tomoaki Sato, Shu Okugawa, Kyoji Moriya and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Impact of Adherence With In-Patient Prospective Audit and Feedback Recommendations on Patient and Economic Outcomes.Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2025
    Article
  3. Correlation between carbapenem susceptibility inAntimicrobial stewardship & healthcare epidemiology : ASHE · 2025
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ryo YamaguchiDepartment of Pharmacy, The University of Tokyo Hospital, Tokyo, Japan.ORCID 0000-0003-2012-0299
Takehito YamamotoDepartment of Pharmacy, The University of Tokyo Hospital, Tokyo, Japan.
Koh OkamotoDepartment of Infectious Diseases, The University of Tokyo Hospital, Tokyo, Japan.
Keita TatsunoDepartment of Infection Control and Prevention, The University of Tokyo Hospital, Tokyo, Japan.
Mahoko IkedaDepartment of Infection Control and Prevention, The University of Tokyo Hospital, Tokyo, Japan.
Takehiro TanakaDepartment of Pharmacy, The University of Tokyo Hospital, Tokyo, Japan.
Yoshitaka WakabayashiDepartment of Infectious Diseases, The University of Tokyo Hospital, Tokyo, Japan.
Tomoaki SatoDepartment of Infection Control and Prevention, The University of Tokyo Hospital, Tokyo, Japan.
Shu OkugawaDepartment of Infectious Diseases, The University of Tokyo Hospital, Tokyo, Japan.ORCID 0000-0003-3455-8291
Kyoji MoriyaDepartment of Infection Control and Prevention, The University of Tokyo Hospital, Tokyo, Japan.
Hiroshi SuzukiDepartment of Pharmacy, The University of Tokyo Hospital, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prospective audit and feedback (PAF) is considered an effective procedure for appropriate antibiotic use. However, its effect on the time to de-escalation is unclear. We aimed to evaluate the effect of daily PAF implementation, focusing on the time to de-escalation of anti-methicillin-resistant Staphylococcus aureus (MRSA) agents as an outcome measure. To this end, a single-center, retrospective, quasi-experimental study including patients treated with intravenous anti-MRSA agents during pre-PAF (April 1, 2014 to March 31, 2015) and post-PAF (April 1, 2015 to March 31, 2016) periods was conducted. The time to de-escalation was estimated using the Kaplan-Meier method, and Cox proportional hazard analysis was performed to assess the effect of daily PAF implementation on the time to de-escalation. Interrupted time series analysis was used to evaluate the relationship between daily PAF implementation and anti-MRSA agent utilization data converted to defined daily dose (DDD) and days of therapy (DOT) per 1,000 patient days. The median time to de-escalation was significantly shorter in the post-PAF period than in the pre-PAF period (6 days vs. 7 days, P < 0.001). According to multivariate analysis, PAF implementation was independently associated with a shorter time to de-escalation (hazard ratio [HR], 1.18; 95% confidence interval [CI], 1.02 to 1.35). There were no significant differences in hospital mortality, 30-day mortality, and length of stay between the two periods. Interrupted time series analysis showed significant reductions in the trends of DDD (trend change, -0.65; 95% CI, -1.20 to -0.11) and DOT (trend change, -0.74; 95% CI, -1.33 to -0.15) between the pre-PAF and post-PAF periods. Daily PAF implementation for patients treated with intravenous anti-MRSA agents led to a shorter time to de-escalation and lower consumption of anti-MRSA agents without worsening the clinically important outcomes.

Indexed as

Antimicrobial StewardshipMethicillin-Resistant Staphylococcus aureusAnti-Bacterial AgentsFeedbackHumansRetrospective StudiesAnti-Bacterial Agents

Identifiers

PMID35905080
PMCPMC9337637

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.