Evidence map›Paper›PMID 35904650›Full record

SynthesisJournal of autism and developmental disorders2023

Factor associated with the occurrence of epilepsy in autism: a systematic review.

Eleni Zarakoviti, Roz Shafran, David Skuse, Amy McTague, Neha Batura, Tom Palmer, Emma Dalrymple, Sophie D Bennett, Colin Reilly

Open access · hybridAbstract readSystematic Review
In one paragraph

Synthesis in Journal of autism and developmental disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Mortality in Autism: A Longitudinal Register-Based Study.Journal of autism and developmental disorders · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Eleni ZarakovitiUCL Great Ormond Street Institute of Child Health (ICH), 30 Guilford Street, WC1N 1EH, London, UK.
Roz ShafranUCL Great Ormond Street Institute of Child Health (ICH), 30 Guilford Street, WC1N 1EH, London, UK.
David SkuseUCL Great Ormond Street Institute of Child Health (ICH), 30 Guilford Street, WC1N 1EH, London, UK.
Amy McTagueUCL Great Ormond Street Institute of Child Health (ICH), 30 Guilford Street, WC1N 1EH, London, UK.
Neha BaturaUCL Institute for Global Health (IGH), 30 Guilford Street, WC1N 1EH, London, UK.
Tom PalmerUCL Institute for Global Health (IGH), 30 Guilford Street, WC1N 1EH, London, UK.
Emma DalrympleUCL Great Ormond Street Institute of Child Health (ICH), 30 Guilford Street, WC1N 1EH, London, UK.
Sophie D BennettUCL Great Ormond Street Institute of Child Health (ICH), 30 Guilford Street, WC1N 1EH, London, UK.
Colin ReillyUCL Great Ormond Street Institute of Child Health (ICH), 30 Guilford Street, WC1N 1EH, London, UK. creilly@youngepilepsy.org.uk.
University College London · GBGreat Ormond Street Hospital · GB

Funding

Autistica AutisticaEpilepsy Research UK Epilepsy Research UKMedical Research Council MR/L001497/1Medical Research Council MR/T007087/1Young Epilepsy Young Epilepsy
6 · The paper itself

Abstract

This systematic review aimed to identify factors significantly associated with the occurrence of epilepsy in autistic individuals and to consider the impact of study quality on findings. Electronic databases were systematically searched on October 2nd, 2020 and records retrieved were limited to those published from 2000 onwards. Study quality was categorised as 'good', 'moderate' or 'weak'. Fifty-three studies were included and in studies where the prevalence of epilepsy was reported (n = 257,892), 18,254 (7%) had co-occurring epilepsy. Intellectual disability/cognitive impairment was the most commonly reported risk factor associated with occurrence of epilepsy in autistic individuals. The evidence supporting other, potentially relevant factors was weak and inconsistent and requires further evaluation. Only 9/53 studies were considered 'good' quality.

Indexed as

Autism Spectrum DisorderAutistic DisorderCognitive DysfunctionEpilepsyHumansPrevalenceAdultsAutismChildrenEpilepsyIntellectual disability

Identifiers

PMID35904650
PMCPMC10499929
OpenAlexW4288705932

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.