ArticleeLife2022
Heritability and cross-species comparisons of human cortical functional organization asymmetry.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- Molecular and cellular correlates of human cortical lateralization.Communications biology · 2026Article
- Bridging glucose metabolism and intrinsic functional organization of the human cortex.Communications biology · 2026Article
- The molecular and cellular underpinnings of human brain lateralization.bioRxiv : the preprint server for biology · 2025Article
- cuBNM: GPU-Accelerated Brain Network Modeling.bioRxiv : the preprint server for biology · 2025Article
- Dynamic changes in hemispheric lateralization in major depressive disorder correlate with neurotransmitter and genetic profiles: a DIRECT consortium study.Translational psychiatry · 2025Article
- Lateralized visuotopic organization in the macaque superior colliculus revealed by fMRI.Progress in neurobiology · 2025Article
- Episode-specific cortical functional connectome reorganization and neurobiological correlates in bipolar disorder: a cross-sectional study.BMC medicine · 2025Article
- Altered Hemispheric Asymmetry of Functional Hierarchy in Schizophrenia.Brain sciences · 2025Article
- Exploring Brain Size Asymmetry and Its Relationship with Predation Risk Among Chinese Anurans.Biology · 2025Article
- Cortical excitability and brain function in patients with insomnia: a pilot transcranial magnetic stimulation and functional near-infrared spectroscopy study.Frontiers in neuroscience · 2025Article
- Microstructural asymmetry in the human cortex.Nature communications · 2024Article
- Heritability of functional gradients in the human subcortico-cortical connectivity.Communications biology · 2024Article
- Resting state neurophysiology of agonist-antagonist myoneural interface in persons with transtibial amputation.Scientific reports · 2024Article
- Topological state-space estimation of functional human brain networks.PLoS computational biology · 2024Article
- Using rare genetic mutations to revisit structural brain asymmetry.Nature communications · 2024Article
- Altered asymmetry of functional connectome gradients in major depressive disorder.Frontiers in neuroscience · 2024Article
- A Comparative Perspective on the Cerebello-Cerebral System and Its Link to Cognition.Cerebellum (London, England) · 2023Review
- Diverging asymmetry of intrinsic functional organization in autism.Molecular psychiatry · 2023Article
- Evolution of Human Brain Left-Right Asymmetry: Old Genes with New Functions.Molecular biology and evolution · 2023Article
- Functional connectivity gradients of the cingulate cortex.Communications biology · 2023Article
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Authors and funding
7 authors at 5 institutions in 4 countries.
Funding
Abstract
The human cerebral cortex is symmetrically organized along large-scale axes but also presents inter-hemispheric differences in structure and function. The quantified contralateral homologous difference, that is asymmetry, is a key feature of the human brain left-right axis supporting functional processes, such as language. Here, we assessed whether the asymmetry of cortical functional organization is heritable and phylogenetically conserved between humans and macaques. Our findings indicate asymmetric organization along an axis describing a functional trajectory from perceptual/action to abstract cognition. Whereas language network showed leftward asymmetric organization, frontoparietal network showed rightward asymmetric organization in humans. These asymmetries were heritable in humans and showed a similar spatial distribution with macaques, in the case of intra-hemispheric asymmetry of functional hierarchy. This suggests (phylo)genetic conservation. However, both language and frontoparietal networks showed a qualitatively larger asymmetry in humans relative to macaques. Overall, our findings suggest a genetic basis for asymmetry in intrinsic functional organization, linked to higher order cognitive functions uniquely developed in humans.
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