ArticleEndocrine connections2022
Resting energy expenditure in children at risk of hypothalamic dysfunction.
Article in Endocrine connections, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 14 citations in OpenAlex.
- Current Approaches and Therapeutic Strategies for Hypothalamic Syndrome in Patients with Childhood-onset Craniopharyngioma.Journal of clinical research in pediatric endocrinology · 2026Review
- Review
- Quality of life, morbidity, mortality, and long-term prognosis after craniopharyngioma.Frontiers in endocrinology · 2026Review
- The Central Control of Energy Metabolism: Hypothalamic Obesity Is Not One Disease.Hormone research in paediatrics · 2026Review
- Management of Acquired Hypothalamic Dysfunction and the Hypothalamic Syndrome; It Is More Than Obesity.Endocrine reviews · 2025Review
- The introduction of a new mobile lifestyle tool in the battle against hypothalamic obesity; the "HAPPYthalamus" application.Obesity pillars · 2025Article
- Resting Energy Expenditure and Metabolic Features in Children With Septo-Optic Dysplasia.Journal of the Endocrine Society · 2025Article
- Outcome measures in Angelman syndrome.Journal of neurodevelopmental disorders · 2024Article
- Treatment and outcome of the Dutch Childhood Craniopharyngioma Cohort study: First results after centralization of care.Neuro-oncology · 2023Article
- Acquired hypothalamic dysfunction in childhood: 'what do patients need?' - an Endo-ERN survey.Endocrine connections · 2023Article
- Approach to the Patient With Hypothalamic Obesity.The Journal of clinical endocrinology and metabolism · 2023Article
- Metabolic syndrome as a common comorbidity in adults with hypothalamic dysfunction.Frontiers in endocrinology · 2022Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Children with suprasellar brain damage are at risk of hypothalamic dysfunction (HD). HD may lead to decreased resting energy expenditure (REE). Decreased REE, however, is not present in all children with HD. Our aim was to assess which children suspect for HD have low REE, and its association with clinical severity of HD or radiological hypothalamic damage. Patients and methods: A retrospective cohort study was performed. Measured REE (mREE) of children at risk of HD was compared to predicted REE (pREE). Low REE was defined as mREE <90% of predicted. The mREE/pREE quotient was associated to a clinical score for HD symptoms and to radiological hypothalamic damage. Results: In total, 67 children at risk of HD (96% brain tumor diagnosis) with a mean BMI SDS of +2.3 ± 1.0 were included. Of these, 45 (67.2%) had low mREE. Children with severe HD had a significant lower mean mREE/pREE quotient compared to children with no, mild, or moderate HD. Mean mREE/pREE quotient of children with posterior hypothalamic damage was significantly lower compared to children with no or anterior damage. Tumor progression or tumor recurrence, severe clinical HD, and panhypopituitarism with diabetes insipidus (DI) were significant risk factors for reduced REE. Conclusion: REE may be lowered in children with hypothalamic damage and is associated to the degree of clinical HD. REE is, however, not lowered in all children suspect for HD. For children with mild or moderate clinical HD symptoms, REE measurements may be useful to distinguish between those who may benefit from obesity treatment that increases REE from those who would be better helped using other obesity interventions.
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