Evidence map›Paper›PMID 35904205›Full record

ReviewJournal of the American Heart Association2022

Contribution of Fetal Magnetocardiography to Diagnosis, Risk Assessment, and Treatment of Fetal Arrhythmia.

Annette Wacker-Gussmann, Janette F Strasburger, Ronald T Wakai

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Journal of the American Heart Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03775954 (Fetal Electrophysiologic Abnormalities in High-risk Pregnancies Associated With Fetal Demise), which is not on this map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03775954 recruitingnot on this map

Fetal Electrophysiologic Abnormalities in High-risk Pregnancies Associated With Fetal Demise

TypeobservationalSponsorMedical College of WisconsinRan2018 to 2028Enrolled30ConditionsHigh Risk Pregnancy, Congenital Heart Disease, Fetal Hydrops, Twin Monochorionic Monoamniotic PlacentaArmsFetal Magnetocardiogram and Neonatal Electrocardiogram, Substudy only: Maternal/Infant Pharmacogenomic assessment postnatally
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

  1. Guideline
  2. Review
  3. Article
  4. Fe-Based Nanocrystalline Magnetic Shielding Cylinder with Subfemtotesla-Level Magnetic Noise.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Observational
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Cellular and Molecular Effects of Magnetic Fields.International journal of molecular sciences · 2024
    Review
  18. The magnetocardiogram.Biophysics reviews · 2024
    Review
  19. Diagnosis and Management of Fetal Arrhythmias in the Current Era.Journal of cardiovascular development and disease · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Annette Wacker-GussmannDepartment of Congential Heart Disease and Pediatric Cardiology German Heart Center Munich Germany.
Janette F StrasburgerDepartments of Pediatrics and Biomedical Engineering Children's Wisconsin and Herma Heart Institute Milwaukee WI.ORCID 0000-0002-6986-2544
Ronald T WakaiDepartment of Medical Physics University of Wisconsin-Madison Madison WI.ORCID 0000-0002-9894-0484
Deutsches Herzzentrum München · DEUniversity of Wisconsin–Madison · US

Funding

Optimized Signal Processing of Fetal MCG R01HL063174 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI WAKAI, RONALD T · 1999 to 2020
$8.4M
Fetal Electrophysiologic Abnormalities in High-risk Pregnancies Associated with Fetal DemiseR01HL143485 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI STRASBURGER, JANETTE F · 2018 to 2021
$2.5M
NHLBI NIH HHS R01 HL063174NHLBI NIH HHS R01 HL143485
6 · The paper itself

Abstract

Background Fetal echocardiography has been the mainstay of fetal arrhythmia diagnosis; however, fetal magnetocardiography (fMCG) has recently become clinically available. We sought to determine to what extent fMCG contributed to the precision and accuracy of fetal arrhythmia diagnosis and risk assessment, and in turn, how this altered pregnancy management. Methods and Results We reviewed fMCG tracings and medical records of 215 pregnancies referred to the Biomagnetism Laboratory, UW-Madison, over the last 10 years, because of fetal arrhythmia or risk of arrhythmia. We compared referral diagnosis and treatment with fMCG diagnosis using a rating scale and restricted our review to the 144 subjects from the tachycardia, bradycardia/AV block, and familial long QT syndrome categories. Additional fMCG findings beyond those of the referring echocardiogram, or an alternative diagnosis were seen in 117/144 (81%), and 81 (56%) were critical changes. Eight (5.5%) had resolution of arrhythmia before fMCG. At least moderate changes in management were seen in 109/144 (76%) fetuses, of which 35/144 (24%) were major. The most diverse fMCG presentation was long QT syndrome, present in all 3 referral categories. Four of 5 stillbirths were seen with long QT syndrome. Nine fetuses showed torsades de pointes ventricular tachycardia, of which only 2 were recognized before fMCG. Conclusions FMCG has a significant impact on prenatal diagnosis and management of arrhythmias or familial arrhythmia risk, which cannot be fully met by existing technology. The combination of fMCG and fetal echocardiography in fetal care centers will be needed in the future to optimize care.

Indexed as

Long QT SyndromeMagnetocardiographyArrhythmias, CardiacElectrocardiographyFemaleFetusHumansPregnancyPrenatal DiagnosisRisk Assessmentelectrocardiographyfetal arrhythmiafetal echocardiographyfetuslong QT syndromemagnetocardiography

Identifiers

PMID35904205
PMCPMC9375504
OpenAlexW4288535522

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.