Evidence map›Paper›PMID 35903952›Full record

ArticleEMBO molecular medicine2022

Liquid biopsy: blood-based analyses of circulating cell-free DNA in xenografts.

Isabel Heidrich, Klaus Pantel

Abstract read
In one paragraph

Article in EMBO molecular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Isabel HeidrichDepartment of Tumor Biology, University Medical, Center Hamburg-Eppendorf, Hamburg, Germany.
Klaus PantelDepartment of Tumor Biology, University Medical, Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0001-5736-2772

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The liquid biopsy concept has been introduced for circulating tumor cells more than 10 years ago (Pantel & Alix-Panabieres, 2010) and rapidly extended to cell-free DNA released from tumor cells (ctDNA; Lo et al, 2021) and other tumor-derived products such as circulating cell-free RNA (noncoding and messenger RNA), extracellular vesicles, or tumor-educated platelets (Alix-Panabières & Pantel, 2021). In this issue of EMBO Molecular Medicine, the report of Sauer et al (2022) demonstrates the feasibility of longitudinal monitoring of disease burden and response using ctDNA from dried blood spots in xenograft models.

Indexed as

Cell-Free Nucleic AcidsCirculating Tumor DNANeoplastic Cells, CirculatingAnimalsBiomarkers, TumorHeterograftsHumansLiquid BiopsyBiomarkers, TumorCell-Free Nucleic AcidsCirculating Tumor DNA

Identifiers

PMID35903952
PMCPMC9358390

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.