ReviewConnective tissue research2023
Impact of aging on tendon homeostasis, tendinopathy development, and impaired healing.
Review in Connective tissue research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 39 citations in OpenAlex.
- Effects of high-intensity and blood-flow-restricted resistance training on tendon adaptations in older men.European journal of applied physiology · 2026Trial
- One-Year Trajectory of Pain, Function, and Health-Related Quality of Life in Patients With Plantar Fasciopathy.Journal of foot and ankle research · 2025Trial
- Greater Protein Intake Emphasizing Lean Beef Does Not Affect Resistance Training-Induced Adaptations in Skeletal Muscle and Tendon of Older Women: A Randomized Controlled Feeding Trial.The Journal of nutrition · 2024Trial
- Are Platelet Volume, Density, and the Homeostatic Blueprint the Missing Link in Platelet-Rich Plasma Therapies? An Evidence-Based Narrative Review.Journal of clinical medicine · 2026Review
- Aged tendons have impaired mechanosensitivity and lower thresholds for injury under dynamic compression.Journal of biomechanics · 2026Article
- The role of tendon and ligament vasculature in ageing and injury.Biogerontology · 2026Review
- Aged Tendons Have Impaired Mechanosensitivity and Lower Thresholds for Injury under Dynamic Compression.bioRxiv : the preprint server for biology · 2026Article
- Characterizing tendon microstructure using metrics associated with the angular dependence of ultrasound backscatter.The Journal of the Acoustical Society of America · 2026Article
- How muscle ageing affects rapid goal-directed movement: mechanistic insights from a simple model.PLoS computational biology · 2026Article
- An overview in tendon's physiology, pathomorphology, and treatment options.Cell and tissue research · 2026Review
- Senescence-associated secretory phenotype: the "pathogenic" factor driving orthopedic degenerative diseases and its regulation.Frontiers in aging · 2026Review
- Age-related differences in MRI signal intensity of the quadriceps and patellar tendons: Implications for ACL graft selection.Journal of experimental orthopaedics · 2026Article
- Ginsenoside Rg5 mitigates tenocyte deathJournal of ginseng research · 2026Article
- Current cutting-edge omics techniques on musculoskeletal tissues and diseases.Bone research · 2025Review
- Biomechanical and Compositional Changes in the Murine Uterus with Age.Annals of biomedical engineering · 2025Article
- Role of the tendon circadian clock in tendinopathy and implications for therapeutics.International journal of experimental pathology · 2025Review
- Comparing clinical outcomes between transosseous patellar suture fixation versus suture anchor repair in the treatment of quadriceps tendon rupture.Journal of clinical orthopaedics and trauma · 2025Article
- Loss ofMatrix biology plus · 2025Article
- Fluoroquinolone-Mediated Tendinopathy and Tendon Rupture.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Minimally invasive needle tenotomy vs. platelet rich plasma injection in the treatment of chronic elbow epicondylitis.JSES international · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Aging is a complex and progressive process where the tissues of the body demonstrate a decreased ability to maintain homeostasis. During aging, there are substantial cellular and molecular changes, with a subsequent increase in susceptibility to pathological degeneration of normal tissue function. In tendon, aging results in well characterized alterations in extracellular matrix (ECM) structure and composition. In addition, the cellular environment of aged tendons is altered, including a marked decrease in cell density and metabolic activity, as well as an increase in cellular senescence. Collectively, these degenerative changes make aging a key risk factor for the development of tendinopathies and can increase the frequency of tendon injuries. However, inconsistencies in the extent of age-related degenerative impairments in tendons have been reported, likely due to differences in how "old" and "young" age-groups have been defined, differences between anatomically distinct tendons, and differences between animal models that have been utilized to study the impact of aging on tendon homeostasis. In this review, we address these issues by summarizing data by well-defined age categories (young adults, middle-aged, and aged) and from anatomically distinct tendon types. We then summarize in detail how aging affects tendon mechanics, structure, composition, and the cellular environment based on current data and underscore what is currently not known. Finally, we discuss gaps in the current understanding of tendon aging and propose key avenues for future research that can shed light on the specific mechanisms of tendon pathogenesis due to aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.