ArticleFrontiers in psychiatry2022
Identifying the Subtypes of Major Depressive Disorder Based on Somatic Symptoms: A Longitudinal Study Using Latent Profile Analysis.
Article in Frontiers in psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed.
- [Evolution and influencing factors of disease burden of depres-sive disorders and depressive levels among Chinese adolescents].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2026Article
- Heterogeneity of depressive symptoms and associated factors in Korean adults: a latent class analysis using a national data survey.Journal of Korean biological nursing science · 2026Article
- Interindividual differences in digital phenotypes of major depressive disorder: A passive sensing study using smartphone and wearable sensor data.Behaviour research and therapy · 2026Article
- Heterogeneity of brain functional connectivity, transcriptome, and neurotransmitter profiles in major depressive disorder.Psychological medicine · 2025Article
- Brain structural and functional aberrant of hippocampal subregions was associated with somatic depression.BMC psychiatry · 2025Article
- Longitudinal association between somatic symptoms and suicidal ideation in adults with major depressive disorder.Frontiers in psychiatry · 2025Article
- Network analysis of somatic symptoms in Chinese patients with depressive disorder.Frontiers in public health · 2023Article
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Abstract
Background: Two-thirds of major depressive disorder (MDD) patients initially present with somatic symptoms, yet no study has used approaches based on somatic symptoms to subtype MDD. This study aimed to classify MDD Methods: Data were obtained from the study of Algorithm Guided Treatment Strategies for Major Depressive Disorder (AGTs-MDD). We recruited 395 subjects who received monotherapy of mirtazapine or escitalopram and conducted 2-, 4-, 6-, 8-, and 12-week follow-up assessments ( Results: Three subtypes of MDD were found, namely, depression with mild somatic symptoms (68.9%), depression with moderate somatic symptoms (19.2%), and depression with severe somatic symptoms (11.9%). Scores of HAMD ( Conclusion: The results indicate that somatic symptoms should be emphasized in patients with MDD, and more attention is needed for those with moderate somatic symptoms, which may be relevant to a worse prognosis.
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