Evidence map›Paper›PMID 35903481›Full record

ArticleFrontiers in microbiology2022

Gut Commensal Fungi Protect Against Acetaminophen-Induced Hepatotoxicity by Reducing

Zhuoen He, Yunong Zeng, Shuyu Li, Lizhen Lin, Ruisi Zhou, Fangzhao Wang, Wenjiao Yang, Yuhao Wu, Junhao Yang, Ali Chen and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Zhuoen HeDepartment of Critical Care Medicine, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.
Yunong ZengSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.
Shuyu LiSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.
Lizhen LinSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.
Ruisi ZhouSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.
Fangzhao WangSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.
Wenjiao YangDepartment of Simulation Center, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Yuhao WuSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.
Junhao YangSchool of Life Science, South China Normal University, Guangzhou, China.
Ali ChenSchool of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Guangzhou, China.
Zhang WangSchool of Life Science, South China Normal University, Guangzhou, China.
Hong YangDepartment of Critical Care Medicine, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.
Xiaoshan ZhaoSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.
Wei XiaoSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.
Lei LiDepartment of Respiratory and Critical Care Medicine, Affiliated Dongguan Hospital, Southern Medical University, Dongguan, China.
Shenhai GongDepartment of Critical Care Medicine, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.
Southern Medical University · CNSouth China Normal University · CNGuangdong Pharmaceutical University · CNThird Affiliated Hospital of Southern Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aims: Drug-induced liver injury (DILI) is a common cause of acute liver failure and represents a significant global public health problem. When discussing the gut-liver axis, although a great deal of research has focused on the role of gut microbiota in regulating the progression of DILI, the gut commensal fungal component has not yet been functionally identified. Methods: Mice were pretreated with fluconazole (FC) to deplete the gut commensal fungi and were then subject to acetaminophen (APAP) gavage. In addition, transcriptome sequencing was performed to identify differentially expressed genes (DEGs) between control and fluconazole-pretreated groups of the mice challenged with APAP. Results: Gut commensal fungi ablation through fluconazole pretreatment predisposed mice to APAP-induced hepatotoxicity, characterized by elevated serum liver enzyme levels and more severe centrilobular necrosis, which appears to be caused by robust inflammation and oxidative stress. The 16S rDNA sequencing results indicated that Conclusion: Our data highlighted the significance of gut commensal fungi in hepatic inflammation and oxidative stress of APAP mice, shedding light on promising therapeutic strategies targeting

Indexed as

acetaminophenacute liver injuryCyp2a5gut fungiinflammationoxidative stress

Identifiers

PMID35903481
PMCPMC9315200
OpenAlexW4285090410

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.