Evidence map›Paper›PMID 35903441›Full record

ArticleAdvanced functional materials2021

Magnetic Living Hydrogels for Intestinal Localization, Retention, and Diagnosis.

Xinyue Liu, Yueying Yang, Maria Eugenia Inda, Shaoting Lin, Jingjing Wu, Yoonho Kim, Xiaoyu Chen, Dacheng Ma, Timothy K Lu, Xuanhe Zhao

Open access · bronzeAbstract read
In one paragraph

Article in Advanced functional materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
12.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 165 citations in OpenAlex.

  1. Review
  2. Article
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  5. Article
  6. Review
  7. Article
  8. Intelligent Soft Opto-Magnetic Robot for Minimally Invasive Interventional Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  9. Biofilms: from the cradle of life to life support.NPJ biofilms and microbiomes · 2026
    Review
  10. Probiotic-Based Materials as Living Therapeutics.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
  11. Multifunctional and Reprogrammable Magnetoactive Graphene Oxide Origami.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Hydrogel-Based Continuum Soft Robots.Gels (Basel, Switzerland) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Xinyue LiuDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Yueying YangDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Maria Eugenia IndaSynthetic Biology Group, Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Shaoting LinDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Jingjing WuDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Yoonho KimDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Xiaoyu ChenDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Dacheng MaSynthetic Biology Group, Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Timothy K LuSynthetic Biology Group, Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Xuanhe ZhaoDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Massachusetts Institute of Technology · US

Funding

Stretchable Hydrogel Bioinks-Enabled Microfluidic Bioprinting of Functional Small-Diameter Blood VesselsR01HL153857 · NHLBI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ZHAO, XUANHE · 2020 to 2024
$2.4M
Engineering “Phagebody” Antimicrobials for Carbapenem-Resistant EnterobacteriaceaeR33AI121669 · NIAID · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LU, TIMOTHY · 2018 to 2020
$1.3M
NHLBI NIH HHS R01 HL153857NIAID NIH HHS R33 AI121669
6 · The paper itself

Abstract

Natural microbial sensing circuits can be rewired into new gene networks to build living sensors that detect and respond to disease-associated biomolecules. However, synthetic living sensors, once ingested, are cleared from the gastrointestinal (GI) tract within 48 hours; retaining devices in the intestinal lumen is prone to intestinal blockage or device migration. To localize synthetic microbes and safely extend their residence in the GI tract for health monitoring and sustained drug release, an ingestible magnetic hydrogel carrier is developed to transport diagnostic microbes to specific intestinal sites. The magnetic living hydrogel is localized and retained by attaching a magnet to the abdominal skin, resisting the peristaltic waves in the intestine. The device retention is validated in a human intestinal phantom and an

Indexed as

blood sensoringestible materialsintestinal retentionmagnetic hydrogelssynthetic biology

Identifiers

PMID35903441
PMCPMC9328153
OpenAlexW3159405326

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.