Evidence map›Paper›PMID 35903351›Full record

ArticleFrontiers in genetics2022

Essential Role of the Innate Immune Adaptor RIP2 in the Response to Otitis Media.

Arwa Kurabi, Jasmine Lee, Kwang Pak, Anke Leichtle, Allen F Ryan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Arwa KurabiDepartment of Surgery, Division of Otolaryngology, University of California, San Diego, San Diego, CA, United States.
Jasmine LeeDivision of Biological Sciences, University of California, San Diego, San Diego, CA, United States.
Kwang PakDepartment of Surgery, Division of Otolaryngology, University of California, San Diego, San Diego, CA, United States.
Anke LeichtleDepartment of Otolaryngology, University of Lübeck, Lübeck, Germany.
Allen F RyanDepartment of Surgery, Division of Otolaryngology, University of California, San Diego, San Diego, CA, United States.
University of California, San Diego · USUniversity of Lübeck · DE

Funding

Middle ear responses in Otitis MediaR01DC000129 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RYAN, ALLEN F. · 1989 to 2021
$6.8M
Innovative therapy for diseases of the middle earR01DC012595 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RYAN, ALLEN F. · 2012 to 2023
$3.3M
Mechanisms of Persistence and Recovery in Otitis MediaR01DC006279 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WASSERMAN, STEPHEN I · 2003 to 2014
$3.1M
NIDCD NIH HHS R01 DC000129NIDCD NIH HHS R01 DC006279NIDCD NIH HHS R01 DC012595
6 · The paper itself

Abstract

Intracellular nucleotide binding and oligomerization domain (NOD) and Toll-like (TLR) receptors have emerged as pivotal sensors of infection. Both Nod1 and Nod2 contain a caspase activation and recruitment domain (CARD) that interacts with the adaptor protein RIP2 (receptor-interaction protein-2). This leads to ubiquitination of RIP2 and in turn to the activation of NFκB and MAPK transcription factors, to command the host defensive response against pathogenic infections. RIP2 is also activated by TLRs 2 and 4, although the mechanism of this activation is less. The role of RIP2 in otitis media (OM) pathogenesis has yet to be examined. Herein, we used

Indexed as

ear infectionsinflammationmucosal immmunityNLR (NOD-like receptors)pro-inflammatory cytokinesreceptor interacting protein 2 (RIP2)TLR—toll-like receptor

Identifiers

PMID35903351
PMCPMC9315102
OpenAlexW4285023429

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.