ArticleFrontiers in endocrinology2022
Lysophosphatidic Acid Improves Human Sperm Motility by Enhancing Glycolysis and Activating L-Type Calcium Channels.
Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 19 citations in OpenAlex.
- Comparison of semen preservation methods and in vitro fertilisation embryo quality in Simmental cattle.Animal bioscience · 2026Article
- Lysine malonylation regulates human sperm motility.Communications biology · 2026Article
- Alterations in the protein lactylation landscape of sperm from patients with varicocele-associated asthenozoospermia.Frontiers in endocrinology · 2026Article
- Novel insights into the lipid signalling in human spermatozoa.Human reproduction (Oxford, England) · 2025Review
- Differential Metabolomic Signatures in Boar Sperm with Varying Liquid Preservation Capacities at 17 °C.Animals : an open access journal from MDPI · 2025Article
- Evaluation of Lysophosphatidic Acid Effects and Its Receptors During Bovine Embryo Development.International journal of molecular sciences · 2025Article
- Lysophosphatidic acid improves development of porcine somatic cell nuclear transfer embryos.Journal of animal science and technology · 2024Article
- Where do obesity and male infertility collide?BMC medical genomics · 2024Article
- Testicular Toxicity in Rats Exposed to AlClBiological trace element research · 2024Article
- Article
- Novel Insights into circRNA Saga Coming from Spermatozoa and Epididymis of HFD Mice.International journal of molecular sciences · 2023Article
- IKBA phosphorylation governs human sperm motility through ACC-mediated fatty acid beta-oxidation.Communications biology · 2023Article
- Alkaline Dilution Alters Sperm Motility in Dairy Goat by Affecting sAC/cAMP/PKA Pathway Activity.International journal of molecular sciences · 2023Article
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10 authors at 4 institutions in 1 country.
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Abstract
Until now, the molecular mechanisms underlining sperm motility defect causing male infertility are still poorly understood. Safe and effective compounds or drugs that can improve sperm motility are also very limited. Lysophosphatidic acid (LPA) is a naturally occurring phospholipid and a bioactive intermediate with multiple biological activities. It has been detected in various body fluids such as serum, plasma, saliva, tears, blister fluids, hen egg white, and ascites from patients with ovarian cancer. LPA is also abundant in seminal plasma and follicular fluid. It enhances follicle stimulation, improves oocyte fertilization, and promotes early embryonic development and embryo implantation. However, the physiological role of LPA in the male reproductive system remains unknown. Here, our study showed that LPA significantly improved the motility parameters of human sperm hyperactivation in a dose-dependent manner. The LPA-induced elevation of sperm motility is dependent on bovine serum albumin (BSA) but independent of the classical BSA-induced sAC/cAMP/PKA signaling pathway. The enhancement of sperm motility by LPA could not be blocked by CCCP, a respiratory inhibitor suppressing mitochondrial ATP production. Moreover, LPA improved the activity of triosephosphate isomerase in glycolysis. Meanwhile, LPA treatment significantly increased ATP and phosphoenolpyruvate levels and decreased ADP content during sperm glycolysis. Notably, none of known or identified LPA receptors was detected in human sperm. Further investigations showed that LPA promoted sperm motility through L-type calcium channels. In summary, this study revealed the involvement of LPA in the regulation for human sperm motility by enhancing glycolysis and activating L-type calcium channels. The current findings may shed new light on the understanding of causes of asthenozoospermia, and indicate that LPA could be used as a novel therapeutic agent to improve sperm function and fertilizing capacity.
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