Evidence map›Paper›PMID 35903199›Full record

ArticleFrontiers in cellular and infection microbiology2022

The Long Non-Coding Antisense RNA JHDM1D-AS1 Regulates Inflammatory Responses in Human Monocytes.

Erik Malmström, Hina N Khan, Cornelis van 't Veer, Melissa Stunnenberg, Mariska T Meijer, Hisatake Matsumoto, Natasja A Otto, Teunis B H Geijtenbeek, Alex F de Vos, Tom van der Poll and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

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  5. Identification of key genes and development of an identifying machine learning model for sepsis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Erik MalmströmAmsterdam University Medical Centers, Center for Experimental and Molecular Medicine, University of Amsterdam, Amsterdam, Netherlands.
Hina N KhanAmsterdam University Medical Centers, Center for Experimental and Molecular Medicine, University of Amsterdam, Amsterdam, Netherlands.
Cornelis van 't VeerAmsterdam University Medical Centers, Center for Experimental and Molecular Medicine, University of Amsterdam, Amsterdam, Netherlands.
Melissa StunnenbergAmsterdam Institute for Infection and Immunity, Amsterdam, Netherlands.
Mariska T MeijerAmsterdam University Medical Centers, Center for Experimental and Molecular Medicine, University of Amsterdam, Amsterdam, Netherlands.
Hisatake MatsumotoAmsterdam University Medical Centers, Center for Experimental and Molecular Medicine, University of Amsterdam, Amsterdam, Netherlands.
Natasja A OttoAmsterdam University Medical Centers, Center for Experimental and Molecular Medicine, University of Amsterdam, Amsterdam, Netherlands.
Teunis B H GeijtenbeekAmsterdam Institute for Infection and Immunity, Amsterdam, Netherlands.
Alex F de VosAmsterdam University Medical Centers, Center for Experimental and Molecular Medicine, University of Amsterdam, Amsterdam, Netherlands.
Tom van der PollAmsterdam University Medical Centers, Center for Experimental and Molecular Medicine, University of Amsterdam, Amsterdam, Netherlands.
Brendon P SciclunaAmsterdam University Medical Centers, Center for Experimental and Molecular Medicine, University of Amsterdam, Amsterdam, Netherlands.
Amsterdam University Medical Centers · NLUniversity of Amsterdam · NLSkåne University Hospital · SEUniversity of Malta · MTVrije Universiteit Amsterdam · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Monocytes are key players in innate immunity, with their ability to regulate inflammatory responses and combat invading pathogens. There is a growing body of evidence indicating that long non-coding RNA (lncRNA) participate in various cellular biological processes, including the innate immune response. The immunoregulatory properties of numerous lncRNAs discovered in monocytes remain largely unexplored. Here, by RNA sequencing, we identified a lncRNA JHDM1D-AS1, which was upregulated in blood monocytes obtained from patients with sepsis relative to healthy controls.

Indexed as

RNA, Long NoncodingHumansLipopolysaccharidesMacrophagesMonocytesRNA, AntisenseLipopolysaccharidesRNA, AntisenseRNA, Long Noncodinginflammationlong non-coding RNAmonocytesepsistoll-like receptors

Identifiers

PMID35903199
PMCPMC9315269
OpenAlexW4285025439

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.