Evidence map›Paper›PMID 35902958›Full record

ReviewStem cell research & therapy2022

Clinical application of mesenchymal stem cell in regenerative medicine: a narrative review.

Ria Margiana, Alexander Markov, Angelina O Zekiy, Mohammed Ubaid Hamza, Khalid A Al-Dabbagh, Sura Hasan Al-Zubaidi, Noora M Hameed, Irshad Ahmad, R Sivaraman, Hamzah H Kzar and 3 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Stem cell research & therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 249 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
249citing papers in PubMed, 5 pooled it
55.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

249 citing papers in PubMed, 5 syntheses or guidelines pooled it, 381 citations in OpenAlex.

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189 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 11 institutions in 6 countries.

Ria MargianaDepartment of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Alexander MarkovTyumen State Medical University, Tyumen, Russian Federation.
Angelina O ZekiyDepartment of Prosthetic Dentistry, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
Mohammed Ubaid HamzaMedical Technical College, Al-Farahidi University, Baghdad, Iraq.
Khalid A Al-DabbaghDepartment of Dentistry, Al-Hadba University College, Mosul, Iraq.
Sura Hasan Al-ZubaidiAnesthesia Techniques Department, Al-Mustaqbal University College, Babylon, Iraq.
Noora M HameedAnesthesia Techniques, Al-Nisour University College, Baghdad, Iraq.
Irshad AhmadDepartment of Medical Rehabilitation Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia.
R SivaramanDepartment of Mathematics, Dwaraka Doss Goverdhan Doss Vaishnav College, Arumbakkam, University of Madras, Chennai, India.
Hamzah H KzarVeterinary Medicine College, Al-Qasim Green University, Al-Qasim, Iraq.
Moaed E Al-GazallyCollege of Medicine, University of Al-Ameed, Karbala, Iraq.
Yasser Fakri MustafaDepartment of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, 41001, Iraq.
Homayoon SiahmansouriDepartment of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. siahmansouri.homa@gmail.com.
University of Mosul · IQAl-Farahidi UniversityAl-Nisour University College · IQKing Khalid University · SAMinistry of Higher Education and Scientific Research · IQSechenov University · RUTabriz University of Medical Sciences · IRTyumen State Medical University · RUUniversitas Dr. Soetomo · IDUniversity of Karbala · IQUniversity of Madras · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The multipotency property of mesenchymal stem cells (MSCs) has attained worldwide consideration because of their immense potential for immunomodulation and their therapeutic function in tissue regeneration. MSCs can migrate to tissue injury areas to contribute to immune modulation, secrete anti-inflammatory cytokines and hide themselves from the immune system. Certainly, various investigations have revealed anti-inflammatory, anti-aging, reconstruction, and wound healing potentials of MSCs in many in vitro and in vivo models. Moreover, current progresses in the field of MSCs biology have facilitated the progress of particular guidelines and quality control approaches, which eventually lead to clinical application of MSCs. In this literature, we provided a brief overview of immunoregulatory characteristics and immunosuppressive activities of MSCs. In addition, we discussed the enhancement, utilization, and therapeutic responses of MSCs in neural, liver, kidney, bone, heart diseases, and wound healing.

Indexed as

Mesenchymal Stem CellsMesenchymal Stem Cell TransplantationImmunomodulationRegenerative MedicineWound HealingCell therapyMesenchymal stromal cellRegenerative medicineStem cell therapyTissue regeneration

Identifiers

PMID35902958
PMCPMC9330677
OpenAlexW4288084885

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.