Evidence map›Paper›PMID 35902860›Full record

ReviewCancer cell international2022

Myricetin: targeting signaling networks in cancer and its implication in chemotherapy.

Zeeshan Javed, Khushbukhat Khan, Jesús Herrera-Bravo, Sajid Naeem, Muhammad Javed Iqbal, Qamar Raza, Haleema Sadia, Shahid Raza, Munir Bhinder, Daniela Calina and 2 more

Open access · goldAbstract readReview
In one paragraph

Review in Cancer cell international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
6.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.

  1. Pooled it
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  13. The role of heat shock protein 90 in idiopathic pulmonary fibrosis: state of the art.European respiratory review : an official journal of the European Respiratory Society · 2025
    Review
  14. Medicinal chemistry (Shariqah (United Arab Emirates)) · 2025
    Article
  15. Article
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  19. Investigation ofPlants (Basel, Switzerland) · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 11 institutions in 5 countries.

Zeeshan JavedOffice of Research Innovation and Commercialization, Lahore Garrison University, Lahore, Pakistan.
Khushbukhat KhanDepartment of Healthcare Biotechnology, Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Sector H-12, Islamabad, 44000, Pakistan.
Jesús Herrera-BravoDepartamento de Ciencias Básicas, Facultad de Ciencias, Universidad Santo Tomas, Santiago, Chile.
Sajid NaeemGansu Key Laboratory of Biomonitoring and Bioremediation for Environmental Pollution, School of Life Sciences, Lanzhou University, Lanzhou, 730000, China.
Muhammad Javed IqbalDepartment of Biotechnology, Faculty of Sciences, University of Sialkot, Sialkot, Pakistan. javed.iqbal@uskt.edu.pk.
Qamar RazaInstitute of Biochemistry and Biotechnology, University of Veterinary and Animal Sciences, Lahore, Punjab, Pakistan.
Haleema SadiaDepartment of Biotechnology, Balochistan University of Information Technology, Engineering and Management Sciences, Quetta, 87100, Pakistan.
Shahid RazaOffice of Research Innovation and Commercialization, Lahore Garrison University, Lahore, Pakistan.
Munir BhinderDepartment of Human Genetics & Molecular Biology, University of Health Sciences, Lahore, 54600, Pakistan.
Daniela CalinaDepartment of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349, Craiova, Romania. calinadaniela@gmail.com.
Javad Sharifi-RadFacultad de Medicina, Universidad del Azuay, Cuenca, Ecuador. javad.sharifirad@gmail.com.
William C ChoDepartment of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong, China. chocs@ha.org.hk.
Lahore Garrison University · PKBalochistan University of Information Technology, Engineering and Management Sciences · PKLanzhou University · CNNational University of Sciences and Technology · PKQueen Elizabeth Hospital · CNUniversidad de La Frontera · CLUniversidad del Azuay · ECUniversity of Health Sciences Lahore · PKUniversity of Medicine and Pharmacy of Craiova · ROUniversity of SialkotUniversity of Veterinary and Animal Sciences · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The gaps between the complex nature of cancer and therapeutics have been narrowed down due to extensive research in molecular oncology. Despite gathering massive insight into the mysteries of tumor heterogeneity and the molecular framework of tumor cells, therapy resistance and adverse side effects of current therapeutic remain the major challenge. This has shifted the attention towards therapeutics with less toxicity and high efficacy. Myricetin a natural flavonoid has been under the spotlight for its anti-cancer, anti-oxidant, and anti-inflammatory properties. The cutting-edge molecular techniques have shed light on the interplay between myricetin and dysregulated signaling cascades in cancer progression, invasion, and metastasis. However, there are limited data available regarding the nano-delivery platforms composed of myricetin in cancer. In this review, we have provided a comprehensive detail of myricetin-mediated regulation of different cellular pathways, its implications in cancer prevention, preclinical and clinical trials, and its current available nano-formulations for the treatment of various cancers.

Indexed as

ApoptosisCancerCell cycleMyricetinNano-deliverySignaling networks

Identifiers

PMID35902860
PMCPMC9336020
OpenAlexW4288447024

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.