ArticleBMC infectious diseases2022
Virulence genes distributed among Staphylococcus aureus causing wound infections and their correlation to antibiotic resistance.
Article in BMC infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 38 citations in OpenAlex.
- Article
- A new Kayvirus vB_SauM-MUHD-1 combats Methicillin-resistant Staphylococcus aureus wound infections.Applied microbiology and biotechnology · 2026Article
- Virulence Profiling of Multidrug-Resistant ClinicalMicrobial drug resistance (Larchmont, N.Y.) · 2026Article
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- Analysis of the virulence potential, ability to form biofilms and susceptibility to bacteriocins ofJournal of veterinary research · 2026Article
- Antimicrobial photodynamic therapy withFrontiers in cellular and infection microbiology · 2026Article
- Nanocurcumin: An Innovative Strategy to Combat Virulence and Methicillin Resistance inIranian journal of medical sciences · 2025Article
- Biofilm production and virulence traits among extensively drug-resistant and methicillin-resistant Staphylococcus aureus from buffalo subclinical mastitis in Bangladesh.Scientific reports · 2025Article
- Characterization of Bacterial Spectrum and Antimicrobial Resistance Patterns in Wound Infections from a Chinese Hospital.Infection and drug resistance · 2025Article
- GENETIC DETERMINANTS OF ANTIBIOTIC RESISTANCE AND VIRULENCE INAfrican journal of infectious diseases · 2025Article
- Article
- Integrating multi-wet laboratory diagnostics to study staphylococci in animals in Uganda.BMC microbiology · 2024Article
- Mec-A Positive Methicillin-SusceptibleReports of biochemistry & molecular biology · 2024Article
- Molecular characterization and antibiotic resistance ofFood science and biotechnology · 2024Article
- Role ofOpen veterinary journal · 2023Article
- Molecular Characterization ofTropical medicine and infectious disease · 2023Article
- Diclofenac and Meloxicam Exhibited Anti-Virulence Activities Targeting Staphyloxanthin Production in Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2023Article
- Tackling strong biofilm and multi-virulent vancomycin-resistantFrontiers in cellular and infection microbiology · 2023Article
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4 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundStaphylococcus aureus causes many human infections, including wound infections, and its pathogenicity is mainly influenced by several virulence factors.
aimThis study aimed to detect virulence genes (hla, sea, icaA, and fnbA) in S. aureus isolated from different wound infections among Egyptian patients admitted to Minia University Hospital. This study also aimed to investigate the prevalence of these genes in methicillin-resistant S. aureus (MRSA), methicillin-susceptible S. aureus (MSSA), and vancomycin-resistant S. aureus isolates and the resistance and sensitivity to different antibiotic classes.
methodsA cross-sectional study was carried out from November 2019 to September 2021. Standard biochemical and microbiological tests revealed 59 S. aureus isolates. The Kirby-Bauer disc diffusion method was used to determine antibiotic susceptibility. DNA was extracted using a DNA extraction kit, and polymerase chain reaction was used to amplify all genes.
resultsA total of 59 S. aureus isolates were detected from 51 wound samples. MRSA isolates accounted for 91.5%, whereas MSSA isolates accounted for 8.5%. The multidrug resistance (MDR) percentage in S. aureus isolates was 54.2%. S. aureus showed high sensitivity pattern against vancomycin, linezolid, and chloramphenicol. However, a high resistance pattern was observed against oxacillin and piperacillin. sea was the most predominant gene (72.9%), followed by icaA (49.2%), hla (37.3%), and fnbA (13.6%). sea was the commonest virulence gene among MRSA isolates (72.2%), and a significant difference in the distribution of icaA was found. However, sea and icaA were the commonest genes among MSSA isolates (79.9%). The highest distribution of sea was found among ciprofloxacin-resistant isolates (95.2%).
conclusionThe incidence of infections caused by MDR S. aureus significantly increased with MRSA prevalence. sea is the most predominant virulence factor among antibiotic-resistant strains with a significant correlation to piperacillin, gentamicin, and levofloxacin.
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