Evidence map›Paper›PMID 35902787›Full record

ArticleJournal of medical virology2022

Initial introduction and spread of the SARS-CoV-2 AY.4.2.1 Delta variant in Bulgaria, a genomic insight.

Ivailo Alexiev, Marta Giovanetti, Eleonora Cella, Ivan Ivanov, Ivan Stoikov, Deyan Donchev, Lubomira Grigorova, Anna Gancheva, Reneta Dimitrova, Nelly Korsun and 7 more

Abstract read
In one paragraph

Article in Journal of medical virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Ivailo AlexievNational Center of Infectious and Parasitic Diseases, Sofia, Bulgaria.
Marta GiovanettiLaboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.ORCID 0000-0002-5849-7326
Eleonora CellaBurnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida, USA.
Ivan IvanovNational Center of Infectious and Parasitic Diseases, Sofia, Bulgaria.ORCID 0000-0002-3186-1124
Ivan StoikovNational Center of Infectious and Parasitic Diseases, Sofia, Bulgaria.
Deyan DonchevNational Center of Infectious and Parasitic Diseases, Sofia, Bulgaria.
Lubomira GrigorovaNational Center of Infectious and Parasitic Diseases, Sofia, Bulgaria.
Anna GanchevaNational Center of Infectious and Parasitic Diseases, Sofia, Bulgaria.
Reneta DimitrovaNational Center of Infectious and Parasitic Diseases, Sofia, Bulgaria.
Nelly KorsunNational Center of Infectious and Parasitic Diseases, Sofia, Bulgaria.ORCID 0000-0002-3188-2283
Ivelina TrifonovaNational Center of Infectious and Parasitic Diseases, Sofia, Bulgaria.
Ivva PhilipovaNational Center of Infectious and Parasitic Diseases, Sofia, Bulgaria.
Veselin DobrinovNational Center of Infectious and Parasitic Diseases, Sofia, Bulgaria.
Iliana GrigorovaNational Center of Infectious and Parasitic Diseases, Sofia, Bulgaria.
Todor KantardjievNational Center of Infectious and Parasitic Diseases, Sofia, Bulgaria.
Iva ChristovaNational Center of Infectious and Parasitic Diseases, Sofia, Bulgaria.ORCID 0000-0002-7878-3995
Massimo CiccozziUnit of Medical Statistics and Molecular Epidemiology, University Campus Bio-Medico of Rome, Rome, Italy.ORCID 0000-0003-3866-9239

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The evolution of the emerging SARS-CoV-2 variants carrying mutations in the spike protein raises concerns about the possibility of accelerated transmission in the ever-evolving COVID-19 pandemic worldwide. AY.4.2, a sublineage of the Delta variant, was considered a variant under investigation (VUI) and also gained the nickname "Delta Plus," due to its extra mutations, Y145H and A222V. In this study, using genomic epidemiology, we provide the first insights into the introduction of AY.4.2 in Bulgaria and the AY.4.2.1 sublineage that found larger dissemination only in Bulgaria and the United Kingdom.

Indexed as

COVID-19SARS-CoV-2BulgariaGenomicsHumansMutationPandemicsSpike Glycoprotein, CoronavirusSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2epidemiologymutation/mutation rateSARS coronavirus

Identifiers

PMID35902787
PMCPMC9353378

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.